150570-99-3

Usage

Uses

Used in Pharmaceutical Research and Development:
4-AMINO-D-PHENYLALANINE METHYL ESTER is used as a key intermediate in the synthesis of various pharmaceutical compounds. Its unique structure allows it to be a building block for the creation of new drugs, particularly those targeting neurological disorders and other conditions that may benefit from the modulation of D-phenylalanine's effects.
Used in Organic Synthesis:
In the field of organic synthesis, 4-AMINO-D-PHENYLALANINE METHYL ESTER serves as a versatile reagent and precursor for the production of a wide range of organic compounds. Its ability to participate in various chemical reactions makes it valuable for the synthesis of complex organic molecules and the development of novel chemical entities.
Used in Protein Structure and Function Studies:
4-AMINO-D-PHENYLALANINE METHYL ESTER is utilized as a research tool in the investigation of protein structure and function. Its incorporation into peptides and proteins can provide insights into the role of D-amino acids in protein folding, stability, and interactions with other biomolecules, contributing to a deeper understanding of biological processes and the design of therapeutic agents.
Used in Neurological Disorder Research:
Given its relationship with D-phenylalanine, 4-AMINO-D-PHENYLALANINE METHYL ESTER may be employed in research aimed at understanding and treating neurological disorders. Its potential to modulate the effects of D-phenylalanine could lead to the development of treatments for conditions such as Parkinson's disease, depression, and other mood disorders.

InChI:InChI=1/C10H14N2O2/c1-14-10(13)9(12)6-7-2-4-8(11)5-3-7/h2-5,9H,6,11-12H2,1H3/t9-/m1/s1

Upstream product

• 81677-60-3 (L)-p-Nitrophenylalanine methyl ester 
• 67-56-1 methanol 
• 943-80-6 4-amino-L-phenylalanine 
• 17193-40-7 (S)-4-nitrophenylalanine methyl ester hydrochloride 
• 2922-41-0 (p-aminophenyl)alanine 

Downstream Products

• 958236-74-3 3-[4-(3-formyl-pyrrol-1-yl)-phenyl]-2-[(1-methyl-cyclohexanecarbonyl)-amino]-propionic acid methyl ester 
• 1140067-35-1 methyl (S)-2-amino-3-[4-(9-fluorenylmethoxycarbonylamino)phenyl]propionate 

Relevant academic research and scientific papers

Photohormones Enable Optical Control of the Peroxisome Proliferator-Activated Receptor γ(PPARγ)

Photopharmacology aims at the optical control of protein activity using synthetic photoswitches. This approach has been recently expanded to nuclear hormone receptors with the introduction of "photohormones"for the retinoic acid receptor, farnesoid X rece

COMPOSITIONS CONTAINING, METHODS INVOLVING, AND USES OF NON-NATURAL AMINO ACIDS AND POLYPEPTIDES

Disclosed herein are non-natural amino acids and polypeptides that include at least one non-natural amino acid, and methods for making such non-natural amino acids and polypeptides. The non-natural amino acids, by themselves or as a part of a polypeptide, can include a wide range of possible functionalities, but typical have at least one aromatic amine group. Also disclosed herein are non-natural amino acid polypeptides that are further modified post-translationally, methods for effecting such modifications, and methods for purifying such polypeptides. Typically, the modified non-natural amino acid polypeptides include at least one alkylated amine group. Further disclosed are methods for using such non-natural amino acid polypeptides and modified non-natural amino acid polypeptides, including therapeutic, diagnostic, and other biotechnology uses.

77. Synthese d'une sonde biotinylee a bras clivable allonge pour l'isolement des recepteurs de l'angiotensine II

We have synthesized a new biotinylated probe for angiotensin II receptors studies; biotinyl-NH(CH2)2-SS-(CH2)2-CO-Gly-εAhx-1,Phe(4N3)8>angiotensin II (5).This molecule can be photoactivated through an arylazido group. 1H-NMR studies suggest that it adopts an extended conformation which should allow a simultaneous recognition of both streptavidin and hormone receptor.It has a good affinity for receptors (Kd= 1 nM) and hence is a promising tool in their detection (autoradiography, gold-, ferritin-, enzyme-, or fluorescent streptavidin derivatives) and separation (cell sorting, affinity chromatography).It can be monoiodinated at its tyrosine residue without a significant loss of affinity.Its extended cleavable arm allows an easy recovery of the probe-receptor'complex from streptavidin.An HPLC monitoring of the synthesis is described, particularly of the segment coupling 1+2 in presence of (benzotriazol-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate (BOP).This method can be used as well for synthesis of the D-Phe8 derivative that has antagonist properties.