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• 185500-56-5 3-Chloro-5-isothiocyanato-benzonitrile 
• 144930-87-0 1-(3-Chloro-5-cyano-phenyl)-3-(1,1-dimethyl-propyl)-thiourea 

Relevant academic research and scientific papers

Nickel(II)-Catalyzed Synthesis of Unsymmetrical Carbodiimides Using Molecular Oxygen as an Oxidant from Isocyanides and Primary Amines

In the course of our studies of a practical synthesis of the antihypertensive drug 1, a general and convenient preparation of N,N'-disubstituted carbodiimides 2 was achieved by the nickel(II)-catalyzed reaction of isocyanides with primary amines, using ox

Synthesis and structure-activity relationships of novel phenylcyanoguanidine derivatives as potassium channel openers

3,5-Di-substituted phenylcyanoguanidine derivatives with halogen, cyano, and/or nitro groups at the 3- and 5-positions of the benzene ring exhibited very strong smooth muscle relaxation activity in vitro, as compared to pinacidil. Among them, N-(3-chloro-5-cyanophenyl)-N'-cyano-N''-tert- pentylguanidine (5s) showed 27-fold more potent activity than pinacidil, and exhibited a stronger and more lasting antihypertensive effect than pinacidil by oral administration to spontaneously hypertensive rats. We propose a new pharmacophore model in which the essential factors for binding to the potassium channel are an NH and a bulky alkyl group.