Nickel(II)-Catalyzed Synthesis of Unsymmetrical Carbodiimides Using Molecular Oxygen as an Oxidant from Isocyanides and Primary Amines

Article abstract of DOI:10.1021/jo00071a021

In the course of our studies of a practical synthesis of the antihypertensive drug 1, a general and convenient preparation of N,N'-disubstituted carbodiimides 2 was achieved by the nickel(II)-catalyzed reaction of isocyanides with primary amines, using ox