1506-96-3Relevant articles and documents
Sulfapyridine-like benzenesulfonamide derivatives as inhibitors of carbonic anhydrase isoenzymes I, II and VI
Alp, Cemalettin,?zsoy, ?eyda,Alp, Nurdan Alcan,Erdem, Deryanur,Gültekin, Mehmet Serdar,Küfrevio?lu, ?mer Irfan,?entürk, Murat,Supuran, Claudiu T.
, p. 818 - 824 (2012)
The inhibition of two human cytosolic carbonic anhydrase (hCA, EC 4.2.1.1) isozymes I, II and human serum isozyme VI, with a series of tosylited aromatic amine derivatives was investigated. The KI ranges of compounds 1-14 and acetazolamide against hCA I ranged between 1.130 and- 448.2 μM, against hCA II between 0.103 and- 14.3 μM, and against hCA VI ranged between 0.340 and- 42.39 μM. Tosylited aromatic amine derivatives are thus interesting hCA I, II and VI inhibitors, and might be used as leads for generating enzyme inhibitors eventually targeting other isoforms which have not been assayed yet for their interactions with such agents.
Palladium-catalyzed arylation of aryl sulfonamides with cyclohexanones
Cao, Xiangxiang,Bai, Yang,Xie, Yanjun,Deng, Guo-Jun
, p. 94 - 100 (2014/01/06)
Pd-catalyzed intermolecular aerobic dehydrogenative aromatizations have been developed for the arylation of aryl sulfonamides with cyclohexanones. Various N-aryl sulfonamides were selectively obtained in good yields using molecular oxygen as oxidant. The reaction tolerated a wide range of functionalities.
