55962-05-5Relevant articles and documents
Mechanistic studies of copper-catalyzed alkene aziridination
Brandt, Peter,Soedergren, Mikael J.,Andersson, Pher G.,Norrby, Per-Ola
, p. 8013 - 8020 (2000)
The mechanism of the copper-catalyzed aziridination of alkenes using [N-(p-toluenesulfonyl)imino]-phenyliodinane (PhINTs) as the nitrene source has been elucidated by a combination of hybrid density functional theory calculations (B3LYP) and kinetic exper
Method for preparing azabicyclic compounds
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Paragraph 0099-0100; 0102, (2021/11/14)
The method comprises the following steps: a compound of the formula II and a compound of the formula III react under the action of a Lewis acid [3 + 2], the azabicyclic compound represented by the formula I is obtained, and the reaction formula is as shown below. The method has the advantages of wide substrate adaptability range, mild reaction conditions, less reaction steps, high atom economy, high yield and stereoselectivity and the like.
Ni-Catalyzed Carboxylation of Aziridines en Route to β-Amino Acids
Davies, Jacob,Janssen-Müller, Daniel,Zimin, Dmitry P.,Day, Craig S.,Yanagi, Tomoyuki,Elfert, Jonas,Martin, Ruben
supporting information, p. 4949 - 4954 (2021/04/07)
A Ni-catalyzed reductive carboxylation of N-substituted aziridines with CO2 at atmospheric pressure is disclosed. The protocol is characterized by its mild conditions, experimental ease, and exquisite chemo- and regioselectivity pattern, thus unlocking a new catalytic blueprint to access β-amino acids, important building blocks with considerable potential as peptidomimetics.