150609-75-9

Upstream product

• 459-46-1 4-Fluorobenzyl bromide 
• 150609-73-7 (1S,2'S,4'R)-<1-<4'-(4''-fluorobenzyl)-5'-oxo-tetrahydrofuran-2'-yl>-2-phenylethyl>carbamic acid tert-butyl ester 
• 193338-94-2 (5S,1'S)-carbetoxy-5-<1-<<(1',1-dimethylothoxy)carbonyl>amino>-2-phenylmethyl>dihydrofuran-2(3H)-one 
• 18162-48-6 tert-butyldimethylsilyl chloride 
• 150609-74-8 (2R,4S,5S)-5-tert-Butoxycarbonylamino-2-(4-fluoro-benzyl)-4-hydroxy-6-phenyl-hexanoic acid 

Relevant academic research and scientific papers

HIV-1 protease inhibitors based on hydroxyethylene dipeptide isosteres: An investigation into the role of the P1' side chain on structure-activity

A systematic investigation was undertaken to determine the role of the P1' sidechain in a series of hydroxyethylene isostere based inhibitors of HIV-1 protease. Substitution and homologation of the benzyl P1' side chain of the Phe-Phe isostere based pseudo peptides 1 (L-682,679) and 2 (L-685,434) with various heteroalkyl groups leads to a series of extremely potent inhibitors of the enzyme. Several examples of the most potent inhibitors were very effective in an ex vivo cell based viral spread assay using human H9 T- lymphocytes and the IIIb isolate of HIV-1. Compound 19 is 120 times more potent than 1 and 16 times more potent than 2 in inhibiting the spread of infection in this assay.