150610-65-4Relevant academic research and scientific papers
Enantioselective α-Benzylation of Acyclic Esters Using π-Extended Electrophiles
Schwarz, Kevin J.,Yang, Chao,Fyfe, James W. B.,Snaddon, Thomas N.
, p. 12102 - 12105 (2018/09/11)
The first asymmetric cooperative Lewis base/palladium catalyzed benzylic alkylation of acyclic esters is reported. This reaction proceeds via stereodefined C1-ammonium enolate nucleophiles. Critical to its success was the identification of benzylic phosphate electrophiles, which were uniquely reactive. Alkylated products were obtained with very high levels of enantioselectivity, and this method has been applied toward the synthesis of the thrombin inhibitor DX-9065a.
Process for preparing 2-phenyl-3-naphthylpropionic acid derivatives
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, (2008/06/13)
A process for preparing a compound represented by general formulae (5) and (6) in the following reaction scheme or salts thereof, wherein R1represents a protective group for a nitrogen atom; R2represents a methanesulfonyl group or p-
Dibasic (Amidinoaryl)propanoic Acid Derivatives as Novel Blood Coagulation Factor Xa Inhibitors
Nagahara, Takayasu,Yokoyama, Yukio,Inamura, Kazue,Katakura, Shin-ichi,Komoriya, Satoshi,et al.
, p. 1200 - 1207 (2007/10/02)
Since activated factor X (FXa) is a coagulant enzyme that generates thrombin and participates in both intrinsic and extrinsic coagulation pathways, inhibition of FXa may be more effective than inactivation of thrombin for interrupting blood coagulation.To
