150618-06-7

Upstream product

• 2916-68-9 2-(Trimethylsilyl)ethanol 
• 201230-82-2 carbon monoxide 
• 123993-20-4 N-tert.-butoxycarbonyl-(4-trifluoromethanesulfonyloxy)-L-phenylalanine benzyl ester 

Downstream Products

• 150618-11-4 (S)-2-Acetylamino-3-[4-(difluoro-phosphono-methyl)-phenyl]-propionic acid 
• 367266-82-8 (S)-4-((S)-2-Acetylamino-3-{4-[2-methoxycarbonyl-2-(triphenyl-λ⁵-phosphanylidene)-acetyl]-phenyl}-propionylamino)-4-[(S)-3-tert-butoxycarbonyl-1-((1S,2S)-1-carbamoyl-2-methyl-butylcarbamoyl)-propylcarbamoyl]-butyric acid tert-butyl ester 
• 367266-74-8 (S)-4-((S)-2-Acetylamino-3-{4-[2-methoxycarbonyl-2-(triphenyl-λ⁵-phosphanylidene)-acetyl]-phenyl}-propionylamino)-4-[(1S,2R)-1-((S)-1-carbamoyl-3-methyl-butylcarbamoyl)-2-hydroxy-propylcarbamoyl]-butyric acid benzyl ester 
• 367266-81-7 (S)-4-{(S)-2-Acetylamino-3-[4-(2-methoxycarbonyl-2-oxo-acetyl)-phenyl]-propionylamino}-4-[(S)-3-tert-butoxycarbonyl-1-((1S,2S)-1-carbamoyl-2-methyl-butylcarbamoyl)-propylcarbamoyl]-butyric acid tert-butyl ester 
• 367266-75-9 (S)-4-{(S)-2-Acetylamino-3-[4-(2-methoxycarbonyl-2-oxo-acetyl)-phenyl]-propionylamino}-4-[(1S,2R)-1-((S)-1-carbamoyl-3-methyl-butylcarbamoyl)-2-hydroxy-propylcarbamoyl]-butyric acid benzyl ester 
• 367266-72-6 3-[4-(2-benzyloxycarbonyl-2-tert-butoxycarbonylamino-ethyl)-phenyl]-3-oxo-2-(triphenyl-λ⁵-phosphanylidene)-propionic acid methyl ester 
• 367266-73-7 3-[4-((S)-2-Acetylamino-2-carboxy-ethyl)-phenyl]-3-oxo-2-(triphenyl-λ⁵-phosphanylidene)-propionic acid methyl ester 
• 460322-88-7 3-[4-((S)-2-Amino-2-carboxy-ethyl)-phenyl]-3-oxo-2-(triphenyl-λ⁵-phosphanylidene)-propionic acid methyl ester 
• 150618-07-8 4-((S)-2-Benzyloxycarbonyl-2-tert-butoxycarbonylamino-ethyl)-benzoic acid 

Relevant academic research and scientific papers

Preparation of L-(Phosphonodifluoromethyl) phenylalanine derivatives as non-hydrolyzable mimetics of O-phosphotyrosine

N-t-BOC-L-(Phosphonodifluoromethyl)phenylalanine benzyl ester (1) was prepared in 5 steps from N-t-BOC-L-tyrosine benzyl eser O-triflate (4). Compound 1 was further converted to derivatives 2 and 3 which are potentially suitable for peptide synthesis. Ana

Selective inhibition of Src SH2 by a novel thiol-targeting tricarbonyl-modified inhibitor and mechanistic analysis by 1H/13C NMR spectroscopy

Detailed analysis of Src SH2 binding by peptides containing a novel tricarbonyl-modified pTyr moiety is described. We envisaged that Src SH2 selectivity might be obtained by exploiting the thiol group of Cys188 present in the pTyr binding pocket of the pr