150666-84-5Relevant academic research and scientific papers
Synthesizing method of 3-sulfonyl alcohol compounds
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Paragraph 0016, (2017/04/03)
The invention discloses a synthesizing method of 3-sulfonyl alcohol compound. The method includes: using substituted sulfohydrazide and propenol compounds as the raw materials to perform reaction in water so as to obtain the 3-sulfonyl alcohol compounds. The method has the advantages that the method uses the substituted sulfohydrazide and the propenol compounds as the raw materials to perform the heating reaction in an aqueous solution without catalysts to directly obtain the 3-sulfonyl alcohol compounds, and the 3-sulfonyl alcohol compounds with the purity being above 80% can be obtained through simple separation after the reaction; the method is few in steps, simple to operate and green, and a new method for synthesizing medical and chemical alcohol compounds is provided for the chemical synthesizing field.
Discovery of a novel series of selective MMP inhibitors: Identification of the γ-sulfone-thiols
Freskos, John N.,Mischke, Brent V.,DeCrescenzo, Gary A.,Heintz, Robert,Getman, Daniel P.,Howard, Susan C.,Kishore, Nandini N.,McDonald, Joseph J.,Munie, Grace E.,Rangwala, Shaukat,Swearingen, Craig A.,Voliva, Charles,Welsch, Dean J.
, p. 943 - 948 (2007/10/03)
We have discovered a new series of potent MMP inhibitors that are selective for MMP-13 over MMP-1 incorporating a γ-sulfone thiol.
