2266-41-3

Basic information

• Product Name: 4-FLUOROBENZENESULFONOHYDRAZIDE
• Synonyms: 4-FLUOROBENZENESULFONOHYDRAZIDE
• CAS NO: 2266-41-3
• Molecular Formula: C₆H₇FN₂O₂S
• Molecular Weight: 190.1953832
• Mol File: 2266-41-3.mol
• Article Data: 53

Chemical Properties

• Melting Point: 87-88 °C
• Boiling Point: 326.4±44.0 °C(Predicted)
• Appearance: /
• Density: 1.447±0.06 g/cm3(Predicted)
• PKA: 8.95±0.10(Predicted)
• CAS DataBase Reference: 4-FLUOROBENZENESULFONOHYDRAZIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-FLUOROBENZENESULFONOHYDRAZIDE(2266-41-3)
• EPA Substance Registry System: 4-FLUOROBENZENESULFONOHYDRAZIDE(2266-41-3)

Safety Data

• Hazardous Substances Data: 2266-41-3(Hazardous Substances Data)

Usage

General Description

4-Fluorobenzenesulfonohydrazide is a chemical compound with the molecular formula C6H6FNO2S. It is a white to off-white crystalline powder with a slightly bitter taste. This chemical is primarily used as a reagent in organic synthesis and pharmaceutical manufacturing. It can also be utilized in the production of agrochemicals and dyes. 4-Fluorobenzenesulfonohydrazide is considered to be a moderately hazardous substance and should be handled with care, as exposure to high concentrations can cause irritation to the skin, eyes, and respiratory system. It is important to follow proper safety protocols when working with this chemical to prevent any potential health risks.

Upstream product

• 349-88-2 4-Fluorobenzenesulfonyl chloride 
• 98-59-9 p-toluenesulfonyl chloride 

Downstream Products

• 1554261-65-2 C₁₆H₁₇FOS 
• 432-99-5 2-[(4-fluorophenyl)sulfonyl]-1-phenylethan-1-one 
• 368-85-4 4-fluorobenzenesulfonyl fluoride 
• 1402459-57-7 ethyl (Z)-3-((4-fluorophenyl)sulfonyl)acrylate 
• 2905-15-9 1-fluoro-4-[(4-fluorobenzenesulfonyl)sulfanyl]benzene 
• 1153-43-1 4,4'-dimethoxyphenyl thiosulfonate 
• 14195-22-3 3-benzyl-4-phenyl-1H-pyrazole 
• 345-83-5 4-fluorobenzophenone 

Relevant articles and documents

Synthesis of symmetrical / unsymmetrical thiosulfonates through the disproportionate coupling reaction of sulfonyl hydrazide mediated by phosphomolybdic acid

Phosphomolybdic acid (H3PMo12O40) is reported as a green low-cost catalyst for the synthesis of symmetrical / unsymmetrical thiosulfonates via the disproportionate coupling reaction of sulfonyl hydrazide. The attributes of this reported catalytic system include low catalyst loadings (1 mol%), efficient turnover, and high yields (up to 94%). Additionally, this reaction mechanism involves the formation of a thiyl radical and sulfonyl radical via sulfinyl radical disproportionation.

Palladium-Catalyzed Direct C-H Arylation of 3-Butenoic Acid Derivatives

We report herein a direct method to synthesize 4-aryl-3-butenoic acid through a carboxylic-acid-directed oxidative Heck reaction. The various 4-aryl-3-butenoic acids are easily prepared in moderate to good yields. In view of the promising bioactivity of 4-phenyl-3-butenoic acid previously reported, its derivatives reported here may be bioactive.

Electrochemical fluorosulfonylation of styrenes

An environmentally friendly and efficient electrochemical fluorosulfonylation of styrenes has been developed. With the use of sulfonylhydrazides and triethylamine trihydrofluoride, a diverse array of β-fluorosulfones could be readily obtained. This reaction features mild conditions and a broad substrate scope, which could also be conveniently extended to a gram-scale preparation.