150709-18-5Relevant academic research and scientific papers
SAR of 2-benzyl-4-aminopiperidines: CGP 49823, an orally and centrally active non-peptide NK1 antagonist
Ofner, Silvio,Hauser, Kathleen,Schilling, Walter,Vassout, Annick,Veenstra, Siem J.
, p. 1623 - 1628 (1996)
Novel 2-benzyl-4-aminopiperidines have been shown to be potent and selective antagonists at the NK1 receptor. Some compounds of this series, e.g. CGP 49823 (2), show CNS activity after oral administration.
