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SAR of 2-benzyl-4-aminopiperidines: CGP 49823, an orally and centrally active non-peptide NK1 antagonist

DOI: 10.1016/0960-894X(96)00287-9

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 1623 - 1628 (1996)

Update date:2022-07-29

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Authors:

Ofner, SilvioOfner, Silvio

Hauser, KathleenHauser, Kathleen

Schilling, WalterSchilling, Walter

Vassout, AnnickVassout, Annick

Veenstra, Siem J.Veenstra, Siem J.

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Article abstract of DOI:10.1016/0960-894X(96)00287-9

Novel 2-benzyl-4-aminopiperidines have been shown to be potent and selective antagonists at the NK1 receptor. Some compounds of this series, e.g. CGP 49823 (2), show CNS activity after oral administration.

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Full text of DOI:10.1016/0960-894X(96)00287-9

Products guided by the article

Product name:(2R,4R)-2-Benzyl-4-((1S,4R)-4,7,7-trimethyl-3-oxo-2-oxa-bicyclo[2.2.1]heptane-1-carbonyloxy)-piperidine-1-carboxylic acid tert-butyl ester

Cas No:150709-18-5

150709-18-5

R&D Labs maybe for 150709-18-5

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