SAR of 2-benzyl-4-aminopiperidines: CGP 49823, an orally and centrally active non-peptide NK1 antagonist

DOI: 10.1016/0960-894X(96)00287-9

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 1623 - 1628 (1996)

Update date:2022-07-29

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Authors:

Ofner, Silvio

Hauser, Kathleen

Schilling, Walter

Vassout, Annick

Veenstra, Siem J.

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Article abstract of DOI:10.1016/0960-894X(96)00287-9

Novel 2-benzyl-4-aminopiperidines have been shown to be potent and selective antagonists at the NK₁ receptor. Some compounds of this series, e.g. CGP 49823 (2), show CNS activity after oral administration.

Full text of DOI:10.1016/0960-894X(96)00287-9

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