150727-72-3

Basic information

• Product Name: 4,6-dichloro-5-(2-Methoxyphenoxy)-2-(pyridin-4-yl)pyriMidine
• Synonyms: 4,6-dichloro-5-(2-Methoxyphenoxy)-2-(pyridin-4-yl)pyriMidine;5-(o-Methoxyphenoxy)-4,6-dichloro-2-(4-pyridyl)pyriMidine;4,6-dichloro-5-(2-methoxyphenoxy)-2-(4-pyridyl)-pyrimidine
• CAS NO: 150727-72-3
• Molecular Formula: C₁₆H₁₁Cl₂N₃O₂
• Molecular Weight: 348.18344
• Mol File: 150727-72-3.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 372.7±42.0 °C(Predicted)
• Appearance: /
• Density: 1.376±0.06 g/cm3(Predicted)
• PKA: 0.21±0.10(Predicted)
• CAS DataBase Reference: 4,6-dichloro-5-(2-Methoxyphenoxy)-2-(pyridin-4-yl)pyriMidine(CAS DataBase Reference)
• NIST Chemistry Reference: 4,6-dichloro-5-(2-Methoxyphenoxy)-2-(pyridin-4-yl)pyriMidine(150727-72-3)
• EPA Substance Registry System: 4,6-dichloro-5-(2-Methoxyphenoxy)-2-(pyridin-4-yl)pyriMidine(150727-72-3)

Safety Data

• Hazardous Substances Data: 150727-72-3(Hazardous Substances Data)

Usage

General Description

The chemical compound 4,6-dichloro-5-(2-Methoxyphenoxy)-2-(pyridin-4-yl)pyriMidine is a heterocyclic organic compound that contains pyrimidine and pyridine rings. It is characterized by the presence of two chlorine atoms and a methoxyphenyl group attached to the pyrimidine ring. 4,6-dichloro-5-(2-Methoxyphenoxy)-2-(pyridin-4-yl)pyriMidine has been studied for its potential use in pharmaceuticals, particularly in the development of novel drugs for various therapeutic purposes. Its unique structure and chemical properties make it a subject of interest for further research and potential applications in the field of medicinal chemistry.

Upstream product

• 1878-85-9 (2-methoxyphenoxy)acetic acid 
• 150726-89-9 (2-methoxyphenoxy)-malonic acid dimethyl ester 
• 38768-62-6 methyl (2-methoxyphenoxy) ethanoate 
• 6345-27-3 4-amidinopyridine hydrochloride 
• 150728-08-8 5-(o-methoxyphenoxy)-4,6-dihydroxy-2-(pyridin-4-yl)-pyrimidine 
• 20730-58-9 2-(2-Methoxyphenoxy)propanedioic acid diethyl ester 

Downstream Products

• 441797-50-8 C₂₃H₂₀ClN₅O₄S 
• 329922-94-3 p-methyl-N-[6-chloro-5-(o-methoxyphenoxy)-2-(pyridin-4-yl)-4-pyrimidinyl]-benzene-sulfonamide 
• 329923-33-3 5-isopropyl-pyridine-2-sulfonic acid [6-chloro-5-(2-methoxy-phenoxy)-2-pyridin-4-yl-pyrimidin-4-yl]-amide 
• 346671-42-9 4-tert-butyl-N-[6-chloro-5-(2-methoxy-phenoxy)-2-(pyridin-4-yl)-pyrimidin-4-yl]-benzenesulfonamide 
• 346671-43-0 4-tert-butyl-N-[6-(4-hydroxy-2-butynyloxy)-5-(o-methoxyphenoxy)-2-(pyridin-4-yl)-4-pyrimidinyl]-benzene sulfonamide 
• 346671-41-8 5-isopropyl-N-[6-(4-hydroxy-2-butynyloxy)-5-(o-methoxyphenoxy)-2-(4-pyridyl)-4-pyrimidinyl]-2-pyridine sulfonamide 
• 329925-10-2 5-methyl-pyridine-2-sulfonic acid [6-(2-amino-ethoxy)-5-(2-methoxy-phenoxy)-2-pyridin-4-yl-pyrimidin-4-yl]-amide 
• 290815-30-4 5-methyl-pyridine-2-sulfonic acid [6-chloro-5-(2-methoxy-phenoxy)-2-pyridin-4-yl-pyrimidin-4-yl]-amide 
• 441797-85-9 4-amino-6-chloro-5-(o-methoxyphenoxy)-2-(4-pyridyl)-pyrimidine 
• 405308-12-5 2-phenyl-ethanesulfonic acid [6-chloro-5-(2-methoxy-phenoxy)-2-pyridin-4-yl-pyrimidin-4-yl]-amide 

Relevant articles and documents

The discovery of N -[5-(4-bromophenyl)-6-[2-[(5-bromo-2-pyrimidinyl)oxy] ethoxy]-4-pyrimidinyl]- N ′-propylsulfamide (macitentan), an orally active, potent dual endothelin receptor antagonist

Starting from the structure of bosentan (1), we embarked on a medicinal chemistry program aiming at the identification of novel potent dual endothelin receptor antagonists with high oral efficacy. This led to the discovery of a novel series of alkyl sulfamide substituted pyrimidines. Among these, compound 17 (macitentan, ACT-064992) emerged as particularly interesting as it is a potent inhibitor of ETA with significant affinity for the ET B receptor and shows excellent pharmacokinetic properties and high in vivo efficacy in hypertensive Dahl salt-sensitive rats. Compound 17 successfully completed a long-term phase III clinical trial for pulmonary arterial hypertension.

SULFONAMIDES

The novel sulfonamides of formula I, STR1 in which the symbols R. sup.1-R 9, R a, R b, X, Y and n have the significance given in the description and salts thereof can be used for the treatment of circulatory disorders, especially hypertension, ischemia, vasopasms and angina pectoris.