150728-12-4

Basic information

• Product Name: 5-(2-Methoxyphenoxy)-[2,2'-bipyrimidine]-4,6(1H,5H)-dione
• Synonyms: 5-(2-methoxyphenoxy)-[2,2'-bipyrimidine]-4,6(1h,5h)-dione;5-(2-methoxyphenoxy)-2-(pyrimidin-2-yl)pyrimidine-4,6(1H,5H)-dione;5-(2-METHOXYPHENOXY)-2-(PYRIMIDIN-2-YL)PYRIMIDINE-4,6(1H,5H)-DIONE,PURITY:98% MIN(HPLC);5-(2-Methoxyphenxoy)-[2,2'-bipyrimidine]-4,6(1H,5H)-dione;5-(O-methoxyphenoxy)-2-pymidin-2-yl)-4,6-(1H,5H)-pymidine dione;Bosentan interMediate;5-(2-Methoxyphenoxy)-2-(pyriMidin-2-yl)-1,4,5,6-tetrahydropyriMidine-4,6-dione;5-(2-Methoxyphenoxy)-[2,2'-BipyriMidine]-4,6(1H,5H)-
• CAS NO: 150728-12-4
• Molecular Formula: C₁₅H₁₂N₄O₄
• Molecular Weight: 312.28
• EINECS: 1806241-263-5
• Product Categories: pyrimidine;Heterocycle-Pyrimidine series
• Mol File: 150728-12-4.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• Density: 1.45
• Storage Temp.: 2-8°C
• PKA: 6.23±0.40(Predicted)
• CAS DataBase Reference: 5-(2-Methoxyphenoxy)-[2,2'-bipyrimidine]-4,6(1H,5H)-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(2-Methoxyphenoxy)-[2,2'-bipyrimidine]-4,6(1H,5H)-dione(150728-12-4)
• EPA Substance Registry System: 5-(2-Methoxyphenoxy)-[2,2'-bipyrimidine]-4,6(1H,5H)-dione(150728-12-4)

Safety Data

• Hazardous Substances Data: 150728-12-4(Hazardous Substances Data)

Usage

General Description

5-(2-Methoxyphenoxy)-[2,2'-bipyrimidine]-4,6(1H,5H)-dione is a chemical compound with the molecular formula C16H11N3O4. It is a synthetic organic compound that belongs to the class of bipyrimidine molecules. This chemical is often used in laboratory research and can also be used in the development of pharmaceuticals and other organic compounds. It is a crystalline solid with a white to off-white color and has a melting point of approximately 245-248 degrees Celsius. In addition, this compound has the potential for various chemical interactions and reactions, making it a valuable tool in the field of organic chemistry.

Upstream product

• 42839-08-7 pyrimidine-2-carboxylic acid ethyl ester 
• 20730-58-9 2-(2-Methoxyphenoxy)propanedioic acid diethyl ester 
• 16879-48-4 2-pyrimidinecarboximidamide benzenesulphonate 
• 14080-23-0 2-cyanopyrimidine 
• 150726-89-9 (2-methoxyphenoxy)-malonic acid dimethyl ester 
• 57871-18-8 methyl ester of imino-pyrimidine acid 
• 90-05-1 2-methoxy-phenol 

Downstream Products

• 1174918-30-9 4-tert-butyl-N-(5-(2-methoxyphenoxy)-6-(2-oxoethoxy)-2,2′-bipyrimidin-4-yl)benzenesulfonamide 
• 1250871-99-8 4-tert-butyl-N-[6-(2,2-diethoxy-ethoxy)-5-(2-methoxyphenoxy)-[2,2']bipyrimidin-4-yl]-benzene sulphonamide 
• 150727-06-3 4-tert-butyl-N-(6-chloro-5-(2-methoxyphenoxy)2,2'-bipyrimidin-4-yl)benzene sulfonamide 
• 157212-55-0 bosentan monohydrate 
• 174227-14-6 p-tert-butyl-N-[6-hydroxy-5-(2-methoxyphenoxy)-2-(2-pyrimidinyl)-4-pyrimidinyl]benzenesulfonamide 
• 301646-60-6 N-[6-[2-(1,1-dimethylethoxy)ethoxy]-5-(2-methoxyphenoxy)[2,2'-bipyrimidin]-4-yl]-4-(1,1-dimethylethyl)benzenesulfonamide 
• 150728-13-5 4,6-dichloro-5-(2-methoxyphenoxy)-2,2'-bipyrimidine 
• 179400-29-4 5-isopropyl-pyridine-2-sulphonic acid 6-(2-hydroxy-ethoxy)-5-(2-methoxy-phenoxy)-2,2'-bipyrimidin-4-ylamide 
• 179400-51-2 5-methyl-pyridine-2-sulphonic acid 6-(2-hydroxy-ethoxy)-5-(2-methoxy-phenoxy)-2,2'-bipyrimidin-4-ylamide 
• 147536-97-8 bosentan 

Relevant articles and documents

A method for the treatment of pulmonary arterial hypertension drug preparation method

The invention provides a preparation method of a therapeutic medicine for treating pulmonary arterial hypertension and particularly provides a preparation method of a key intermediate compound as shown in a formula (IV). According to the method, the compound as shown in the formula (IV) is obtained by means of reaction of a compound as shown in a formula (II) and a compound as shown in a formula (III). The preparation method is easily available in raw materials, low in cost, mild in condition and suitable for industrialized production. The formulae (IV), (II) and (III) are as shown in the specification.

PROCESS FOR PREPARATION OF ENDOTHELIAL RECEPTOR ANTAGONIST (BOSENTAN)

The present invention relates to processes for the preparation of an endothelial receptor antagonist. The present invention particularly relates to synthesis of 4-tert-butyl-N-[6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)-2-(2-pyrimidinyl)-4-pyrimidinyl]benzene sulfonamide (bosentan).