1507357-37-0Relevant academic research and scientific papers
Metal-Free Synthesis of 3-Arylquinolin-2-ones from Acrylic Amides via a Highly Regioselective 1,2-Aryl Migration: An Experimental and Computational Study
Liu, Le,Zhang, Tonghuan,Yang, Yun-Fang,Zhang-Negrerie, Daisy,Zhang, Xinhao,Du, Yunfei,Wu, Yun-Dong,Zhao, Kang
, p. 4058 - 4065 (2016/06/08)
Combined experimental and theoretical investigations into the phenyliodine bis(trifluoroacetate) (PIFA)-mediated reaction of N-arylcinnamamide to produce 3-arylquinolin-2-one derivatives have been conducted. High regioselectivity during the aryl migration process was observed in 3,3-disubstituted acrylamides. Density functional theory calculation was conducted in an attempt to understand the mechanism and the origin of the regioselectivity. On the basis of both the experimental and the theoretical results, a mechanism involving an oxidative annulation, followed by an aryl migration, has been proposed. The annulation is the regioselectivity determining step.
Silver-catalyzed radical tandem cyclization for the synthesis of 3,4-disubstituted dihydroquinolin-2(1 H)-ones
Mai, Wen-Peng,Wang, Ji-Tao,Yang, Liang-Ru,Yuan, Jin-Wei,Xiao, Yong-Mei,Mao, Pu,Qu, Ling-Bo
supporting information, p. 204 - 207 (2014/01/23)
A silver-catalyzed tandem decarboxylative radical addition/cyclization of N-arylcinnamamides with aliphatic carboxylic acids is reported. This method affords a novel and straightforward route to various 3,4-disubstituted dihydroquinolin-2(1H)-ones in aque
The synthesis of 3,4-disubstituted dihydroquinolin-2(1H)-one under metal-free conditions in aqueous solution
Wang, Hongyan,Sun, Bin,Yang, Jun,Wang, Jitao,Mao, Pu,Yang, Liangru,Mai, Wenpeng
, p. 542 - 545 (2014/12/10)
A novel route toward 3,4-disubstituted dihydroquinolin-2(1H )-ones via radical process has been developed in aqueous solution without metals. This method offers a new and simple route for the synthesis of skeleton of dihydroquinolin-2(1H )-one in one step
Silver-catalyzed radical tandem cyclization: An approach to direct synthesis of 3-acyl-4-arylquinolin-2(1 H)-ones
Mai, Wen-Peng,Sun, Gang-Chun,Wang, Ji-Tao,Song, Ge,Mao, Pu,Yang, Liang-Ru,Yuan, Jin-Wei,Xiao, Yong-Mei,Qu, Ling-Bo
, p. 8094 - 8102 (2015/03/18)
A silver-catalyzed efficient and practical synthesis of 3-acyl-4-arylquinolin-2(1H)-ones or 3-acyl-4-aryldihydroquinolin-2(1H)-ones through intermolecular radical addition/cyclization in aqueous solution is reported. This method provides a novel, highly e
