1507382-75-3Relevant academic research and scientific papers
Optimal axial alkylpyridinium-bonded tricationic P-porphyrin in photodynamic inactivation of Escherichia coli
Matsumoto, Jin,Yasuda, Masahide
, p. 1478 - 1484 (2018)
Alkylpyridinium (Apy)-bonded porphyrins have received considerable attention as singlet-oxygen (1O2) sensitizers for photodynamic inactivation (PDI). It is expected that the introduction of Apy makes porphyrins water-soluble and enha
Spectroscopic analysis of the interaction of human serum albumin with tricationic phosphorus porphyrins bearing axial pyridinio groups
Matsumoto, Jin,Kubo, Tomoya,Shinbara, Tomohiko,Matsuda, Naomi,Shiragami, Tsutomu,Fujitsuka, Mamoru,Majima, Tetsuro,Yasuda, Masahide
, p. 1240 - 1247 (2014/01/06)
Much attention has been paid to water-soluble porphyrins and metalloporphyrins as potential sensitizers for photodynamic therapy (PDT). Thus, water-soluble tricationic phosphorus porphyrin complexes were prepared via the introduction of an N-alkylpyridinio group on the axial ligands of phosphorus porphyrins. The resulting tricationic phosphorus porphyrins readily dissolve in aqueous solutions without the formation of aggregates, even at high concentration. Moreover, the affinity of the porphyrins to human serum albumin (HSA) is a key factor in their application to PDT since HSA plays an important role in the transport of drug molecules to a target cell. Interactions between the tricationic phosphorus porphyrins and HSA were examined on the basis of changes in the Soret bands of the absorption and fluorescence spectra of phosphorus porphyrin solutions in the presence of HSA and the fluorescence quenching of HSA by the tricationic phosphorus porphyrins. Tricationic phosphorus porphyrins with moderately long alkyl chains on the pyridinio group were strongly adsorbed on the HSA at a position near the tryptophan residue of HSA. This result suggests that tricationic phosphorus porphyrins containing alkyl groups are good candidates as PDT reagents because of their high water solubility and high affinity for HSA.
