150749-03-4Relevant articles and documents
Synthesis of a naturally occurring diene-containing amino acid and its glutamyl dipeptide via N-acyliminium ion chemistry
Berkheij, Martin,Dijkink, Jan,David, Olivier R. P.,Sonke, Theo,Ijzendoorn, Denis R.,Blaauw, Richard H.,Van Maarseveen, Jan H.,Schoemaker, Hans E.,Hiemstra, Henk
experimental part, p. 914 - 924 (2009/04/11)
The syntheses of the naturally occurring unusual unsaturated amino acid (S)-2-amino-3-methylene-4-pentenoic acid and the corresponding γ-glutamyl dipeptide are described. Key steps are an N-acyliminium ion addition using allenylmethylsilane as nucleophile and an enzymatic resolution mediated by the L-aminopeptidase from Pseudomonas putida. Wiley-VCH Verlag GmbH & Co. KGaA, 2008.
Identification of compounds that inhibit replication of human immunodeficiency virus
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, (2008/06/13)
The present invention relates to the discovery of a novel class of compounds that inhibit the replication of human immunodeficiency virus (HIV) and approaches to identify these compounds. More specifically, it has been found that enzymatically prepared al
Zinc mediated addition of active halides to a glycine cation equivalent: Synthesis of N-Boc-L-propargylglycine
Abood, Norman A.,Nosal, Roger
, p. 3669 - 3672 (2007/10/02)
The reaction of allylic, benzylic and propargylic halides with zine in the presence of the glycine cation equivalent, methyl N-Boc-2-acetoxyglycine, affords Boc protected amino acid derivatives in high yield. Resolution of methyl N-Boc- propargylglycine w