109745-70-2Relevant academic research and scientific papers
SYNTHESE HETEROCYCLISCHER -OXO-ESSIGSAEUREESTER MIT EINEM NEUEN ACYLANIONAEQUIVALENT
Waldner, Adrian
, p. 6059 - 6062 (1986)
The synthesis of new heterocyclic -oxo-acetic acid esters with the novel and easily available acylanion equivalent 5 is described.
Imidazole based solid-supported catalysts for the benzoin condensation
Storey, John M.D.,Williamson, Craig
, p. 7337 - 7339 (2005)
New polymer-supported imidazolium salts have been synthesised, and their utility as pre-catalysts in the benzoin reaction has been demonstrated.
Quinoline compound as well as preparation method, pharmaceutical composition and application thereof
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Paragraph 0369-0372, (2021/03/05)
The invention discloses a compound shown as a general formula I, pharmaceutically acceptable salt or metabolite of the compound, and a preparation method, a pharmaceutical composition and applicationof the compound. The compound shown in the general formula I, the pharmaceutically acceptable salt thereof or the metabolite thereof has a good treatment effect on virus infection, has small toxic andside effects, and can be used for preventing or treating virus infection.
POLYCYCLIC-CARBAMOYLPYRIDONE COMPOUNDS AND THEIR USE FOR THE TREATMENT OF HIV INFECTIONS
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Page/Page column 79, (2015/02/02)
Compounds for use in the treatment of human immunodeficiency virus (HIV) infection are disclosed. The compounds have the following Formula (I): including stereoisomers and pharmaceutically acceptable salts thereof, wherein R1, X, Y1, Y2, or L are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.
CROSSLINKING AGENT, CROSSLINKED POLYMER, AND USES THEREOF
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Page/Page column 20, (2010/08/22)
There is provided a novel crosslinking agent for use in crosslinked polymer fabrication, specifically a crosslinking agent containing at least one compound selected from glyoxylate and a glyoxylic acid ester derivative represented by the following general formula (1): wherein R1 and R2 each independently represents an alkyl group having 1 to 10 carbon atoms and R3 represents a hydrogen atom or an alkyl group having 1 to 10 carbon atoms.
Experimental and DFT study of the aza-Diels-Alder reaction between cyclopentadiene and protonated benzylimine derivated from glyoxylates
Rodríguez-Borges, José Enrique,García-Mera, Xerardo,Fernández, Franco,Lopes, V. Hugo C.,Magalh?es,Cordeiro, M. Natália D. S.
, p. 10951 - 10957 (2007/10/03)
The Diels-Alder reaction of protonated N-benzyl imine of methyl glyoxylate with cyclopentadiene in different solvents gave mixtures of exo/endo adducts. The exo/endo selectivity of the reaction was elucidated by NMR experiments. Theoretical calculations by means of density functional theory (DFT) at the B3LYP/6-31G(d) level have also been performed to elucidate the molecular mechanism of this reaction. The DFT results suggest a highly asynchronous concerted mechanism, which in turn can explain the preferred exo stereoselectivity of the reaction. Inclusion of solvent effects enhances the exo selectivity, and this effect increases with the polarity of the solvent, in good agreement with the experimental findings.
IMPROVED SYNTHESIS OF THE BIOLOGICALLY ACTIVE METHIONINE ANALOG, L-2-AMINO-4-METHOXY-CIS-BUT-3-ENOIC ACID (L-CIS-AMB) USING AN ELECTROPHILIC GLYCINATE SYNTHON
Alks, Vitauts,Sufrin, Janice R.
, p. 1479 - 1486 (2007/10/02)
An improved synthesis of the methionine analog L-cis-AMB, is reported.The key step involves condensation of cis-methoxyvinyllithium with N-acetyl-α-bromoglycine methyl ester to give N-acetyl-DL-cis-AMB methyl ester, the penultimate intermediate of L-cis-AMB synthesis.
About the Ozone Cleavage of Chloroprene and of 2-Chloro-3-methyl-1,3-butadiene in Methanol
Griesbaum, Karl,Meister, Martin
, p. 1573 - 1580 (2007/10/02)
Monoozonolyses of chloroprene (1a) and of 2-chloro-3-methyl-1,3-butadiene (1b) in methanol occur with more than 90percent at the non-chlorinated double bonds to afford the corresponding α,β-unsaturated oxo compounds 2 with selectivities of 96 and 80percent respectively.The latter subsequently react with methanol, and 2a also with the complementary fragment methoxymethyl hydroperoxide (5).The α,β-unsaturated methoxy hydroperoxides 3 which have also been obtained, are less stable than similarly structured, non-α-chlorinated methoxy hydroperoxides.Diozonolyses of 1a and 1b in methanol afforded in 50-60percent the corresponding α-oxocarboxylates (21) and/or the corresponding ketals.In addition, anomalous products were obtained viz. ca. 15percent of methyl hydroxyacetate (12d) from 1a and 1b, as well as ca. 30percent of dimethyl oxalate (27b) from 1a and ca. 35percent of methyl acetate (13) from 1b.The modes of formation of these products have been postulated according to model reactions.
Formation of 4,6-Dinitro-2-nitrosoaniline by Intramolecular Redox Reaction of Esters and Amides of 2-(2,4,6-Trinitroaniline) Carboxylic Acids
Machacek, Vladimir,Hassanien, Makky M.M.,Sterba, Vojeslav,Lycka, Antonin
, p. 867 - 874 (2007/10/02)
The reaction of methyl and ethyl esters of N-(2,4,6-trinitrophenyl)glycine and N-(2,4,6-trinitrophenyl)-α-alanine (3a-d) with methoxide ion in methanol produces 4,6-dinitro-2-nitrosoaniline (4).N-(2,4,6-Trinitrophenyl)glycine methylamide (1d) gives, under the same conditions, the nitroso compound (4) in addition to 12percent of the spiro adduct (2d).A reaction mechanism is suggested, and the influence of the side chain on the reaction kinetics has been studied.
