150749-32-9 Usage
Source
Derived from the root of the ipecac plant
Classification
Potent alkaloid
Medicinal Properties
Emetic (induces vomiting)
Anti-protozoal agent (treats parasitic infections)
Historical Use
Treatment for amoebic dysentery and other parasitic infections
Decline in Use
Replaced by safer and more effective therapies
Mechanism of Action
Inhibits protein synthesis in parasites, leading to their death
Potential Cancer Treatment
Induces apoptosis (cell death) in tumor cells
Toxic Effects
Limited clinical use due to toxic effects and narrow therapeutic window
Legal Status
Schedule I substance by the United States Controlled Substances Act
Check Digit Verification of cas no
The CAS Registry Mumber 150749-32-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,5,0,7,4 and 9 respectively; the second part has 2 digits, 3 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 150749-32:
(8*1)+(7*5)+(6*0)+(5*7)+(4*4)+(3*9)+(2*3)+(1*2)=129
129 % 10 = 9
So 150749-32-9 is a valid CAS Registry Number.
150749-32-9Relevant academic research and scientific papers
Bandara, H. M. Dhammika,Hua, Zhengmao,Zhang, Mei,Pauff, Steven M.,Miller, Stephen C.,Davie, Elizabeth A. Colby,Kobertz, William R.
, p. 8199 - 8205 (2017)
Potassium (K+) exits electrically excitable cells during normal and pathophysiological activity. Currently, K+-sensitive electrodes and electrical measurements are the primary tools to detect K+ fluxes. Here, we describe the synthesis of a near-IR, oxazine fluorescent K+ sensor (KNIR-1) with a dissociation constant suited for detecting changes in intracellular and extracellular K+ concentrations. KNIR-1 treatment of cells expressing voltage-gated K+ channels enabled the visualization of intracellular K+ depletion upon channel opening and restoration of cytoplasmic K+ after channel closing.
