15075-11-3

Upstream product

• 1033617-26-3 3-O-[3-O-methyl-β-D-glucopyranosyl-(1->3)-β-D-glucopyranosyl-(1->4)-β-D-quinovopyranosyl-(1->2)-4-O-sodiumsulfato-β-D-xylopyranosyl]-22-oxo-9(11)-holostene-3β,12α,17α-triol 
• 1082071-34-8 3-O-[3-O-methyl-β-D-glucopyranosyl-(1->3)-β-D-glucopyranosyl-(1->4)-β-D-quinovopyranosyl-(1->2)-4-O-sodiumsulfato-β-D-xylopyranosyl]-22-oxo-9(11)-holostene-3β,12α,25-triol 
• 915213-96-6 fuscocineroside B 

Downstream Products

• 21569-62-0 D-erythro-3-deoxy-pentonic acid 
• 21569-63-1 3-Desoxy-D-threo-pentonsaeure 
• 35522-76-0 O³-methyl-D-threo-[2]pentosulose-bis-phenylhydrazone 
• 35506-61-7 ((3aR,5R,6S,6aR)-6-Methoxy-2,2-dimethyl-tetrahydro-furo[2,3-d][1,3]dioxol-5-yl)-methanol 
• 107280-94-4 O³-methyl-D-threo-[2]pentosulose-bis-(4-bromo-phenylhydrazone) 

Relevant academic research and scientific papers

Two new holostan-type triterpene glycosides from the sea cucumber Bohadschia marmorata Jaeger

Two new holostan-type triterpene glycosides, 17-hydroxy fuscocineroside B (1) and 25-hydroxy fuscocineroside B (2), together with a known triterpene glycoside, fuscocineroside B (3) were isolated from the sea cucumber Bohadschia marmorata JAEGER. The structures of the new triterpene glycosides were elucidated on the basis of spectroscopic analyses and chemical reactions. Compounds 1 and 3 showed considerable antifungal activities against six strains.

New triterpene glycosides from the far eastern starfish solaster pacificus and their biological activity

Three new triterpene glycosides, pacificusosides A–C (1–3), and three previously known triterpene glycosides, cucumariosides C1 (4), C2 (5), and A10 (6), were isolated from the alcoholic extract of the Far Eastern starfish Solaster pacificus. The structures of 1–3 were elucidated by extensive NMR and ESIMS techniques and chemical transformations. Compound 1 has a novel, unique structure, containing an aldehyde group of side chains in its triterpene aglycon. This structural fragment has not previously been found in the sea cucumber triterpene glycosides or starfish steroidal glycosides. Probably, pacificusoside A (1) is a product of the metabolism of the glycoside obtained through dietary means from a sea cucumber in the starfish. Another two new triterpene glycosides (2, 3) have closely related characteristics to sea cucumber glycosides. The cytotoxicity of compounds 1–6 was tested against human embryonic kidney HEK 293 cells, colorectal carcinoma HT-29 cells, melanoma RPMI-7951 cells, and breast cancer MDA-MB-231 cells using MTS assay. Compounds 4–6 revealed the highest cytotoxic activity against the tested cell lines, while the other investigated compounds had moderate or slight cytotoxicity. The cytotoxic effects of 2–6 were reduced by cholesterol like the similar effects of the previously investigated individual triterpene glycosides. Compounds 3, 4, and 5 almost completely suppressed the colony formation of the HT-29, RPMI-7951, and MDA-MB-231 cells at a nontoxic concentration of 0.5 μM.

Two antifungal active triterpenoid saponins from the seeds of Lathyrus plants

Two novel triterpenoid glycosides have been isolated from butanolic seeds extract of two varieties of Lathyrus plants, i.e. Lathyrus ratan and Lathyrus aphaca. Their structures were elucidated as 3-O-[β-D-glucuronopyranosyl- (1→4)-α-L-arabinopyranosyl-(1→2)-α-L-arabinopyranosyl] -olean-11,13 (18)-dien-28-oic acid (1) and 3-O-{β-D-xylopyranosyl-(1 → 2)-β-D-glcopyranosyl-(1→4)-[β-D-glucopyranosyl-(1→2)]- α-D-xylopyranosyl}-2, 16-dihydroxy-4-hydroxymethyl urs-12-en-28-oic acid (2) on the basis of spectral evidences, i.e. FTIR, 1H-NMR, 13C-NMR, ESI-MS and FAB-MS data. The isolated saponins were tested for their antifungal activity. Compound 1 showed maximum inhibition against Colletotrichum dematium (77.8%), whereas compound 2 showed maximum inhibition against Alternaria alternata (53.9%).