35506-61-7Relevant articles and documents
Furan glucosyl triazole type compound and preparation method and bactericide thereof
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, (2018/04/21)
The invention relates to the field of bactericidal compounds, in particular to a furan glucosyl triazole type compound and a preparation and a bactericide thereof. The molecular formula of the furan glucosyl triazole type compound is shown in the following description, wherein R1 is methyl or benzyl, and R2 are phenyl and derivative of the phenyl or ethyl derivatives. Based on structural characteristics of the substrate fructose-6-phosphate and an ISOM catalytic hypothesis mechanism, the inventor adopts a five-membered furan glucose derivative with a similar structure as a basic skeleton, introduces an effective active group triazole structure of pesticides, designs a series of novel furan glucosyl triazole type compounds for the first time, studies the biological activities of the furan glucosyl triazole type compound, examines structure-activity relationships of the furan glucosyl triazole type compound, and lays the foundation for selecting better inhibitors.
MODIFIED RNAI AGENTS
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, (2017/07/14)
One aspect of the present invention relates to double-stranded RNAi (dsRNA) duplex agent capable of inhibiting the expression of a target gene in vivo. The dsRNA duplex comprises one or more xylo modifications in one or both strand. Other aspects of the invention relates to pharmaceutical compositions comprising these dsRNA agents suitable for in vivo therapeutic use, and methods of inhibiting the expression of a target gene by administering these dsRNA agents, e.g., for the treatment of various disease conditions.
β-Oxygen effect in the Barton-McCombie deoxygenation reaction: Further experimental and theoretical findings
Sanchez-Eleuterio, Alma,Sandoval-Lira, Jacinto,Garcia-Sanchez, Jenny,Monterrosas-Perez, Lorena,Hernandez-Perez, Julio M.,Quintero, Leticia,Sartillo-Piscil, Fernando
, p. 9127 - 9136 (2013/10/08)
The chemistry of (S)-methyl xanthates derived from xylo- and ribo-furanose derivatives in the presence of the stannyl radical is investigated. Xanthate derived from β-xylo-furanose affords exclusively a deoxygenated product; whereas, under the same reacti
Inhibition of S-ribosylhomocysteinase (LuxS) by substrate analogues modified at the ribosyl C-3 position
Wnuk, Stanislaw F.,Robert, Jenay,Sobczak, Adam J.,Meyers, Brandon P.,Malladi, Venkata L.A.,Zhu, Jinge,Gopishetty, Bhaskar,Pei, Dehua
experimental part, p. 6699 - 6706 (2009/12/24)
S-Ribosylhomocysteinase (LuxS) catalyzes the cleavage of the thioether bond of S-ribosylhomocysteine (SRH) to produce homocysteine and 4,5-dihydroxy-2,3-pentanedione (DPD), which is the precursor of type 2 autoinducer for bacterial cell-cell communication. In this work, we have synthesized several SRH analogues modified at the ribose C3 position as potential inhibitors of LuxS. While removal or methylation of the C3-OH resulted in simple competitive inhibitors of moderate potency, inversion of the C3 stereochemistry or substitution of fluorine for C3-OH resulted in slow-binding inhibitors of improved potency. The most potent inhibitor showed a KI* value of 0.43 μM.
Novel D-xylose derivatives stimulate muscle glucose uptake by activating AMP-activated protein kinase α
Gruzman, Arie,Shamni, Ofer,Yakir, Moriya Ben,Sandovski, Daphna,Elgart, Anna,Alpert, Evgenia,Cohen, Guy,Hoffman, Amnon,Katzhendler, Yehoshua,Cerasi, Erol,Sasson, Shlomo
body text, p. 8096 - 8108 (2009/12/07)
Type 2 diabetes mellitus has reached epidemic proportions; therefore, the search for novel antihyperglycemic drugs is intense. We have discovered that D-xylose increases the rate of glucose transport in a non-insulin-dependent manner in rat and human myot
Beneficial effect of internal hydrogen bonding interactions on the β-fragmentation of primary alkoxyl radicals. Two-step conversion of D-xylo- and D-ribofuranoses into L-threose and D-erythrose, respectively
Hernandez-Garcia, Luis,Quintero, Leticia,Sanchez, Mario,Sartillo-Piscil, Fernando
, p. 8196 - 8201 (2008/02/13)
(Chemical Equation Presented) Primary alkoxyl free radicals were generated from their readily synthesized N-phthalimido derivatives under reductive conditions. Primary alkoxyl radicals derived from their corresponding xylo- and ribofuranose derivatives underwent, exclusively, an unusual β-fragmentation affording L-threose and D-erythrose derivatives, respectively. This occurs because the alkoxyl radical is capable of achieving an internal hydrogen-bonding interaction leading to a stable six-membered ring intramolecular hydrogen-bonded structure. When the hydroxyl group is protected, the β-fragmentation pathway is prevented and the hydrogen atom transfer (HAT) pathway occurs. Computational studies provided strong support for the experimental observations.
Selective cleavage of methoxy protecting groups in carbohydrates
Boto, Alicia,Hernandez, Dacil,Hernandez, Rosendo,Suarez, Ernesto
, p. 1938 - 1948 (2007/10/03)
The selective cleavage of methoxy protecting groups next to hydroxy groups is achieved using a radical hydrogen abstraction reaction as the key step. Under the reaction conditions, the hydroxy group generates an alkoxyl radical that reacts with the sterically accessible adjacent methoxy group, which is transformed into an acetal. In the second step, the acetals are hydrolyzed to give alcohols or diols. A one-pot hydrogen abstraction-hydrolysis procedure was also developed. Good yields were usually achieved, and the mild conditions of this methodology were compatible with different functional groups and sensitive substrates such as carbohydrates.
Chemoselective deprotection of trityl ethers using silica-supported sodium hydrogen sulfate
Das, Biswanath,Mahender, Gurram,Sunil Kumar, Vooturi,Chowdhury, Nikhil
, p. 6709 - 6711 (2007/10/03)
A highly selective method for the cleavage of trityl ethers over a wide range of functional groups has been developed using silica-supported sodium hydrogen sulfate (NaHSO4-SiO2) as a heterogeneous catalyst. The conversion occurred at room temperature and the yields of the alcohols were found to be excellent.
A facile and chemoselective cleavage of trityl ethers by indium tribromide
Yadav,Reddy, B.V. Subba,Srinivas,Maiti
, p. 528 - 529 (2007/10/03)
Trityl ethers are chemoselectively, deprotected to the corresponding alcohols in high yields by a catalytic amount of indium tribromide in aqueous acetonitrile. The method is compatible with various functional groups such as acetonides, acetates, benzoates, olefins, carbamates, esters and ethers present in the substrate.
A mild and selective cleavage of trityl ethers by CBr4-MeOH
Yadav, Jhillu S.,Subba Reddy, Basi V.
, p. 885 - 888 (2007/10/03)
Trityl ethers are selectively deprotected to the corresponding alcohols in high yields by CBr4 in refluxing methanol under neutral reaction conditions. Other hydroxyl protecting groups like isopropylidene, allyl, benzyl, acetyl, benzoyl, methyl
