150766-86-2

Usage

Uses

Used in Pharmaceutical Industry:
4-BROMOMETHYLBIPHEBYL-2'-CARBOXYLIC ACID is used as an intermediate in the preparation of antihypertensive agents, which are medications designed to treat high blood pressure. Its chemical structure allows it to be a key component in the synthesis of these drugs, contributing to their effectiveness in managing hypertension.
Used in Chemical Synthesis:
4-BROMOMETHYLBIPHEBYL-2'-CARBOXYLIC ACID is also used as an impurity of Telmisartan (D294250), which is an angiotensin II receptor antagonist used to treat hypertension. Its presence in the synthesis process may affect the purity and quality of the final product, making it an important compound to consider during the manufacturing of Telmisartan and other related pharmaceuticals.

Upstream product

• 7148-03-0 o-tolylbenzoic acid 
• 118-92-3 anthranilic acid 

Downstream Products

• 144701-48-4 telmisatran 

Relevant academic research and scientific papers

Method for preparing telmisartan and intermediates thereof

Disclosed is a telmisartan preparation method, characterized in that: 2-n-propyl-4-methyl-6-(1-methyl benzimidazole-2-yl) benzimidazole (compound I) and 4'-halomethyl diphenyl-2-substituted compound (compound II) conduct a nucleophilic substitution reaction to obtain a compound III; when R is COOH, the compound III is telmisartan; and when R is COOR' or CN, the compound III can be hydrolyzed to obtain telmisartan.

Process for brominating the side chain of 4-methylbiphenyl derivatives substituted in the 2' position

A process for preparing 4-bromomethylbiphenyl derivatives substituted in the 2′ position of general formula (I) 1by brominating 4-methylbiphenyl derivatives substituted in the 2′ position of general formula (II) 2wherein: R is CN, COOR1, CONR1R2, or C(OR3)=NR4, or 5-tetrazolyl optionally substituted by benzyl, methyloxycarbonyl, ethyloxycarbonyl, 9-fluorenylmethyloxycarbonyl, 2,2,2-trichloroethyloxycarbonyl, benzyloxycarbonyl, tert-butyloxycarbonyl, allyloxycarbonyl, trichloroacetyl, trifluoroacetyl, or trityl; R1 and R2 which are identical or different are hydrogen or C1-C6-alkyl; R3 and R4 together are a C2-C3-alkylene bridge optionally mono-, di-, tri-, or tetra- substituted by one or more of the groups methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, tert-butyl, phenyl, or naphthyl, wherein the brominating is carried out by means of an N-bromoimide or N-bromoamide in a solvent of organic carboxylic acid esters.

Method for preparing bromomenthyl-biphenyl derivatives

The present invention relates to a process for the preparation of 4′-bromomethyl-biphenyl derivatives of the formula: by reacting a 4′-methyl-biphenyl derivative of the formula: with a brominating agent a in a hydrobromic acid/alkali metal bromate system in a two-phase medium, and under photo-iradiation, where R is as defined in the specification.

Synthesis of 2-substituted-1-benzimidazoles

A four step synthetic sequence leading to the title compounds through the formation of 4'-methylbiphenyl-2-carboxylic acid via catalysed "Gomberg reaction" is described.

Process for producing 4-bromomethylbiphenyl compounds

A process for the production of a compound of general formula STR1 wherein R represents cyano, carboxy which may be esterified or amidated or tetrazolyl which may be substituted, comprising brominating the corresponding methyl compound with a brominating agent such as N -bromoacetamide, N-bromophtalimide, N-bromosuccinimide and so on in a halogenated hydrocarbon solvent in the presence of an azobis compound.