1507941-60-7Relevant academic research and scientific papers
6-phosphorylated phenanthridines from 2-isocyanobiphenyls via radical C-P and C-C bond formation
Zhang, Bo,Daniliuc, Constantin Gabriel,Studer, Armido
supporting information, p. 250 - 253 (2014/01/23)
A C-P bond and a C-C bond are formed in the synthesis of 6-phosphorylated phenanthridines starting with readily prepared 2-isocyanobiphenyls and commercially available P-radical precursors. The radical cascade reaction comprises addition of an oxidatively generated P-centered radical to the isonitrile functionality and subsequent homolytic aromatic substitution. Various 6-phosphorylated phenanthridines are formed in moderate to excellent yield. In contrast to the currently intensively investigated direct arene phosphorylation, the arene core is constructed with concomitant phosphorylation using this approach.
