150802-85-0

Basic information

• Product Name: <(1S)-1-<(2R)-2-(2,4-difluorophenyl)-2-oxiranyl>ethyl> benzoate
• Synonyms: <(1S)-1-<(2R)-2-(2,4-difluorophenyl)-2-oxiranyl>ethyl> benzoate
• CAS NO: 150802-85-0
• Molecular Weight: 304.293
• Mol File: 150802-85-0.mol

Chemical Properties

• CAS DataBase Reference: <(1S)-1-<(2R)-2-(2,4-difluorophenyl)-2-oxiranyl>ethyl> benzoate(CAS DataBase Reference)
• NIST Chemistry Reference: <(1S)-1-<(2R)-2-(2,4-difluorophenyl)-2-oxiranyl>ethyl> benzoate(150802-85-0)
• EPA Substance Registry System: <(1S)-1-<(2R)-2-(2,4-difluorophenyl)-2-oxiranyl>ethyl> benzoate(150802-85-0)

Safety Data

• Hazardous Substances Data: 150802-85-0(Hazardous Substances Data)

Upstream product

• 150802-96-3 (2S,3R)-3-(2,4-Difluorophenyl)-3,4-epoxy-2-butanol 
• 1972-28-7 diethylazodicarboxylate 
• 150802-97-4 [(1R)-1-[(2R)-2-(2,4-difluorophenyl)-2-oxiranyl]ethyl] 3,5-dinitrobenzoate 
• 212890-35-2 2-[(1R)-1-(3,4,5,6-Tetrahydro-2H-pyran-2-yl)oxyethyl]-2-(2,4-difluorophenyl)oxirane 
• 126918-35-2 (1R)-1-<(2R)-2-(2,4-difluorophenyl)-2-oxiranyl>ethanol 
• 65-85-0 benzoic acid 

Downstream Products

• 126918-33-0 (1S)-1-<(2R)-2-(2,4-difluorophenyl)-2-oxiranyl>ethanol 
• 150802-87-2 (2S)-2-(2,4-difluorophenyl)-2-<(1R)-1-(2H-tetrazol-2-yl)ethyl>oxirane 
• 150802-88-3 (2S)-2-(2,4-difluorophenyl)-2-<(1R)-1-(1H-tetrazol-1-yl)ethyl>oxirane 
• 155431-23-5 2-<(1R,2S)-2-(2,4-difluorophenyl)-2,3-epoxy-1-methylpropyl>-4-(4-fluorophenyl)-3(2H,4H)-1,2,4-triazolone 
• 155431-43-9 4-<(1R,2S)-2-(2,4-difluorophenyl)-2,3-epoxy-1-methylpropyl>-2-(4-fluorophenyl)-3(2H,4H)-1,2,4-triazolone 
• 155431-57-5 1-<(1R,2S)-2-(2,4-difluorophenyl)-2,3-epoxy-1-methylpropyl>-4-(4-fluorophenyl)-5(1H,4H)-tetrazolone 
• 155431-33-7 4-{(R)-1-[(S)-2-(2,4-Difluoro-phenyl)-oxiranyl]-ethyl}-2-(4-trifluoromethyl-phenyl)-2,4-dihydro-[1,2,4]triazol-3-one 
• 155431-31-5 2-[(1R,2S)-2-(2,4-difluorophenyl)-2,3-epoxy-1-methylpropyl]-4-(4-trifluoromethylphenyl)-3(2H,4H)-1,2,4-triazolone 
• 155431-50-8 1-{(R)-1-[(S)-2-(2,4-Difluoro-phenyl)-oxiranyl]-ethyl}-4-(4-trifluoromethyl-phenyl)-1,4-dihydro-tetrazol-5-one 
• 155431-36-0 2-[(1R,2S)-2-(2,4-difluorophenyl)-2,3-epoxy-1-methylpropyl]-4-(4-trifluoromethoxyphenyl)-3(2H,4H)-1,2,4-triazolone 
• 155431-76-8 4-{(R)-1-[(S)-2-(2,4-Difluoro-phenyl)-oxiranyl]-ethyl}-2-(4-trifluoromethoxy-phenyl)-2,4-dihydro-[1,2,4]triazol-3-one 
• 155431-94-0 2-[(1R,2S)-2-(2,4-difluorophenyl)-2,3-epoxy-1-methylpropyl]-4-[4-(2,2,2-trifluoroethoxy)phenyl]-3(2H,4H)-1,2,4-triazolone 
• 155431-99-5 4-[(1R,2S)-2-(2,4-difluorophenyl)-2,3-epoxy-1-methylpropyl]-2-[4-(2,2,2-trifluoroethoxy)phenyl]-3(2H,4H)-1,2,4-triazolone 
• 155431-79-1 1-[(1R,2S)-2-(2,4-difluorophenyl)-2,3-epoxy-1-methylpropyl]-4-(4-trifluoromethoxyphenyl)-5(1H,4H)-tetrazolone 

Relevant articles and documents

Azole compounds, their production and use

PCT No. PCT/JP96/00325 Sec. 371 Date Oct. 17, 1996 Sec. 102(e) Date Oct. 17, 1996 PCT Filed Feb. 15, 1996 PCT Pub. No. WO96/25410 PCT Pub. Date Aug. 20, 1996The present invention provides an azole compound represented by the formula (I): wherein Ar is an

Optically active antifungal azoles. VI. Synthesis and antifungal activity of N-[(1R,2R)-2-(2,4-difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl) propyl]-N′-(4-substituted phenyl)-3(2H,4H)-1,2,4-triazolones and 5(1H,4H)-tetrazolones

A new series of optically active antifungal azoles, N-[(1R,2R)-2-(2,4-difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl) propyl]-N′-(4-substituted phenyl)-3(2H,4H)-1,2,4-triazolones (1,2) and 5(1H,4H)-tetrazolones (3), were prepared from the triflate derivative of (1S)-1-[(2R)-2-(2,4-difluorophenyl)-2-oxiranyl]ethanol (13) by an SN2 displacement reaction with the union of an azolone (17-19) and subsequent ring-opening reaction with 1H-1,2,4-triazole. The optically active oxiranylethanol 13 was synthesized from methyl (R)-lactate in a stereocontrolled manner. The azolones 1-3 prepared showed potent antifungal activities in vitro and in vivo.

Optically active tetrazole compounds, and fungicidal compositions thereof

An optically active azole compound of the formula (I): STR1 wherein R1 and R2 are independently a hydrogen atom, a halogen atom, a haloalkyl group, a haloalkoxy group or an optionally substituted nitrogen-containing heterocyclic group; R3 is a hydrogen atom or an acyl group; Q is CH or N; --NA is a nitrogen-containing aromatic five-membered heterocyclic group having at least two adjacent nitrogen atoms as the ring-constituting atoms which may be substituted, or an aromatic condensed heterocyclic group having two or more nitrogen atoms as the ring-constituting atoms which may be substituted; and (R) shows that the carbon atom marked with (R) has R-configuration; provided that either of R1 and R2 is an optionally substituted nitrogen-containing heterocyclic group when --NA is an 1H-1,2,4-triazol-1-yl group, or a salt thereof, which is useful as an antifungal agent.