150814-00-9Relevant articles and documents
Metformin-conjugated micellar system with intratumoral pH responsive de-shielding for co-delivery of doxorubicin and nucleic acid
Liu, Yanhua,Sun, Jingjing,Huang, Yixian,Chen, Yichao,Li, Jiang,Liang, Lei,Xu, Jieni,Wan, Zhuoya,Zhang, Bei,Li, Zuojun,Li, Song
, (2021)
A novel PMet-P(cdmPEG2K) polymeric micellar carrier was developed for tumor-targeted co-delivery of DOX and nucleic acids (NA), based on polymetformin and a structure designed to lose the PEG shell in response to the acidic extracellular tumor
PRODUCTION METHOD FOR AMIDATE COMPOUND
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Paragraph 0150-0152, (2020/02/13)
A method for producing an amidate compound represented by Formula (3), comprising reacting a urethane compound represented by Formula (1) with a carboxylate compound represented by Formula (2): (in the formulas, A, n, R1, R2, R3, R4, R5, R6, X, and a are as described in the Description).
Targeted cutaneous delivery of ciclosporin A using micellar nanocarriers and the possible role of inter-cluster regions as molecular transport pathways
Lapteva, Maria,Santer, Verena,Mondon, Karine,Patmanidis, Ilias,Chiriano, Gianpaolo,Scapozza, Leonardo,Gurny, Robert,M?ller, Michael,Kalia, Yogeshvar N.
supporting information, p. 9 - 18 (2015/02/19)
Oral administration of ciclosporin A (CsA) is indicated in the treatment of severe recalcitrant plaque psoriasis. However, CsA is both nephro- and hepatotoxic and its systemic administration also exposes the patient to other severe side effects. Although