1245657-05-9Relevant academic research and scientific papers
Targeted cutaneous delivery of ciclosporin A using micellar nanocarriers and the possible role of inter-cluster regions as molecular transport pathways
Lapteva, Maria,Santer, Verena,Mondon, Karine,Patmanidis, Ilias,Chiriano, Gianpaolo,Scapozza, Leonardo,Gurny, Robert,M?ller, Michael,Kalia, Yogeshvar N.
, p. 9 - 18 (2014)
Oral administration of ciclosporin A (CsA) is indicated in the treatment of severe recalcitrant plaque psoriasis. However, CsA is both nephro- and hepatotoxic and its systemic administration also exposes the patient to other severe side effects. Although
Facile synthesis of a fluorescent cyclosporin A analogue to study cyclophilin 40 and cyclophilin 18 ligands
Gaali, Steffen,Kozany, Christian,Hoogeland, Bastiaan,Klein, Marielle,Hausch, Felix
scheme or table, p. 536 - 539 (2011/03/20)
There are strong indications for the involvement of cyclophilin 40 in diseases caused by misregulation of steroid hormone receptors, like prostate or breast cancer. To identify novel inhibitors for this immunophilin, we developed a simplified fluorescence
