150852-72-5

Usage

Uses

Used in Pharmaceutical Industry:
(R)-1-Cyclopentyl-ethylamine is used as a chiral building block for the synthesis of various drugs and active pharmaceutical ingredients. Its unique stereochemistry allows for the creation of enantiomerically pure compounds, which is crucial for the development of effective and safe medications.
Used in Organic Synthesis:
(R)-1-Cyclopentyl-ethylamine is used as a reagent in the synthesis of various organic compounds. Its ability to act as a chiral building block makes it a valuable component in the creation of complex molecules with specific properties and functions.

Upstream product

• 6004-60-0 1-cyclopentylethanone 
• 540-69-2 ammonium formate 
• 279-24-3 2-aza-bicyclo[2.2.1]heptane 

Relevant academic research and scientific papers

Ruthenium Catalyzed Direct Asymmetric Reductive Amination of Simple Aliphatic Ketones Using Ammonium Iodide and Hydrogen

The direct conversion of ketones into chiral primary amines is a key transformation in chemistry. Here, we present a ruthenium catalyzed asymmetric reductive amination (ARA) of purely aliphatic ketones with good yields and moderate enantioselectivity: up to 99 percent yield and 74 percent ee. The strategy involves [Ru(PPh3)3H(CO)Cl] in combination with the ligand (S,S)-f-binaphane as the catalyst, NH4I as the amine source and H2 as the reductant. This is a straightforward and user-friendly process to access industrially relevant chiral aliphatic primary amines. Although the enantioselectivity with this approach is only moderate, to the extent of our knowledge, the maximum ee of 74 percent achieved with this system is the highest reported till now apart from enzyme catalysis for the direct transformation of ketones into chiral aliphatic primary amines.

Process for making 1-cyclopentylalyl amines useful for the synthesis of sweeteners

The disclosed process relates to a method for preparing 1-cyclopentylalkyl amines, useful in the synthesis of artificial sweeteners, by reducing an azanorbornene in a high-yield one-step reduction of an azanorbornene, wherein the method involves use of a solvent reductant system with catalyst that is compatible with the production of edible food compositions.