150852-72-5 Usage
Description
(R)-1-Cyclopentyl-ethylamine, also known as (R)-N-Cyclopentylethylamine or (R)-N-Ethylcyclopentylamine, is a chiral amine with the molecular formula C8H17N. It is a colorless liquid with a boiling point of 131-132 °C and a melting point of -55 °C. As a chiral building block, it is commonly used in the synthesis of pharmaceuticals and other organic compounds.
Uses
Used in Pharmaceutical Industry:
(R)-1-Cyclopentyl-ethylamine is used as a chiral building block for the synthesis of various drugs and active pharmaceutical ingredients. Its unique stereochemistry allows for the creation of enantiomerically pure compounds, which is crucial for the development of effective and safe medications.
Used in Organic Synthesis:
(R)-1-Cyclopentyl-ethylamine is used as a reagent in the synthesis of various organic compounds. Its ability to act as a chiral building block makes it a valuable component in the creation of complex molecules with specific properties and functions.
Check Digit Verification of cas no
The CAS Registry Mumber 150852-72-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,5,0,8,5 and 2 respectively; the second part has 2 digits, 7 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 150852-72:
(8*1)+(7*5)+(6*0)+(5*8)+(4*5)+(3*2)+(2*7)+(1*2)=125
125 % 10 = 5
So 150852-72-5 is a valid CAS Registry Number.
150852-72-5Relevant articles and documents
Ruthenium Catalyzed Direct Asymmetric Reductive Amination of Simple Aliphatic Ketones Using Ammonium Iodide and Hydrogen
Ernst, Martin,Ghosh, Tamal,Hashmi, A. Stephen K.,Schaub, Thomas
supporting information, (2020/07/14)
The direct conversion of ketones into chiral primary amines is a key transformation in chemistry. Here, we present a ruthenium catalyzed asymmetric reductive amination (ARA) of purely aliphatic ketones with good yields and moderate enantioselectivity: up to 99 percent yield and 74 percent ee. The strategy involves [Ru(PPh3)3H(CO)Cl] in combination with the ligand (S,S)-f-binaphane as the catalyst, NH4I as the amine source and H2 as the reductant. This is a straightforward and user-friendly process to access industrially relevant chiral aliphatic primary amines. Although the enantioselectivity with this approach is only moderate, to the extent of our knowledge, the maximum ee of 74 percent achieved with this system is the highest reported till now apart from enzyme catalysis for the direct transformation of ketones into chiral aliphatic primary amines.
