150877-23-9Relevant academic research and scientific papers
Discovery of 4,4-disubstituted quinazolin-2-ones as T-type calcium channel antagonists
Barrow, James C.,Rittle, Kenneth E.,Reger, Thomas S.,Yang, Zhi-Qiang,Bondiskey, Phung,McGaughey, Georgia B.,Bock, Mark G.,Hartman, George D.,Tang, Cuyue,Ballard, Jeanine,Kuo, Yuhsin,Prueksaritanont, Thomayant,Nuss, Cindy E.,Doran, Scott M.,Fox, Steven V.,Garson, Susan L.,Kraus, Richard L.,Li, Yuxing,Marino, Michael J.,Kuzmick Graufelds, Valerie,Uebele, Victor N.,Renger, John J.
scheme or table, p. 75 - 79 (2010/11/17)
A novel series of quinazolinone T-type calcium channel antagonists have been prepared and evaluated using in vitro and in vivo assays. Optimization of the screening hit 3 by modifications of the 3- and 4-positions of the quinazolinone ring afforded potent
