150878-42-5Relevant articles and documents
Discovery of 4,4-disubstituted quinazolin-2-ones as T-type calcium channel antagonists
Barrow, James C.,Rittle, Kenneth E.,Reger, Thomas S.,Yang, Zhi-Qiang,Bondiskey, Phung,McGaughey, Georgia B.,Bock, Mark G.,Hartman, George D.,Tang, Cuyue,Ballard, Jeanine,Kuo, Yuhsin,Prueksaritanont, Thomayant,Nuss, Cindy E.,Doran, Scott M.,Fox, Steven V.,Garson, Susan L.,Kraus, Richard L.,Li, Yuxing,Marino, Michael J.,Kuzmick Graufelds, Valerie,Uebele, Victor N.,Renger, John J.
, p. 75 - 79 (2010/11/17)
A novel series of quinazolinone T-type calcium channel antagonists have been prepared and evaluated using in vitro and in vivo assays. Optimization of the screening hit 3 by modifications of the 3- and 4-positions of the quinazolinone ring afforded potent
