15088-35-4Relevant academic research and scientific papers
Aromatic isophthalamides aggregate in lipid bilayers: Evidence for a cooperative transport mechanism
Berry, Stuart N.,Busschaert, Nathalie,Frankling, Charlotte L.,Salter, Dale,Gale, Philip A.
supporting information, p. 3136 - 3143 (2015/04/27)
The synthesis and anion transport properties of a series of transmembrane anion transporters based on an isophthalamide scaffold with phenyl, naphthyl or anthracenyl central rings are reported. Anion transport studies using POPC vesicles, showed that the
Aromatic analogs of arcaine inhibit MK-801 binding to the NMDA receptor
Sharma, Terre A.,Carr, Andrew J.,Davis, Rebecca S.,Reynolds, Ian J.,Hamilton, Andrew D.
, p. 3459 - 3464 (2007/10/03)
Aromatic analogs of arcaine were shown to have inhibitory effects on the binding of the channel blocking drug [3H]MK-801 to the NMDA receptor complex. The most potent compound of the series was an N,N - bis(propyl)guanidinium which inhibited [3H]MK-801 binding with an IC50 of 0.58 μM and an IC50 of 12.17 μM upon addition of 100 μM spermidine. The increase in IC50 upon addition of spermidine suggests competitive antagonism between the inhibitor and spermidine at the arcaine-sensitive polyamine site of the NMDA receptor complex.
Aminolysis of N-acyllactams
Stehlicek, Jaroslav,Sebenda, Jan
, p. 2524 - 2531 (2007/10/02)
The overall second-order rate constants of aminolysis of N-benzoyllactams of different ring size, the rate constants of aminolysis of N,N'-isophthaloyl- and N,N'-terephthaloylbis(6-hexanelactam) to the first and second stages and the ratio of splitting of the exocyclic and endocyclic amide bond by octylamine were determined in THF at 50 deg C.The effect of the type of amine and medium on the rate of aminolysis was examined.
