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15088-78-5

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15088-78-5 Usage

Uses

Different sources of media describe the Uses of 15088-78-5 differently. You can refer to the following data:
1. Bis(phenylacetyl)disulfide as sulfur substitution agent in preparation of RNA oligonucleotides.
2. Phenylacetyl disulfide (PADS) may be used as a sulphur transfer agent during the synthesis of phosphorothioate oligodeoxyribonucleotides.

General Description

Phenylacetyl disulphide serves as a sulfurization reagent during the preparation of phosphates.Phenyl acetyl disulfide can be synthesized by the reaction of phenyl benzenethiolsulfonate with thioacetic acid in the presence of triethylamine.

Check Digit Verification of cas no

The CAS Registry Mumber 15088-78-5 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,5,0,8 and 8 respectively; the second part has 2 digits, 7 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 15088-78:
(7*1)+(6*5)+(5*0)+(4*8)+(3*8)+(2*7)+(1*8)=115
115 % 10 = 5
So 15088-78-5 is a valid CAS Registry Number.
InChI:InChI=1/C16H14O2S2/c17-15(11-13-7-3-1-4-8-13)19-20-16(18)12-14-9-5-2-6-10-14/h1-10H,11-12H2

15088-78-5 Well-known Company Product Price

  • Brand
  • (Code)Product description
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  • Packaging
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  • Detail
  • TCI America

  • (B3623)  Bis(phenylacetyl) Disulfide  >98.0%(HPLC)

  • 15088-78-5

  • 5g

  • 580.00CNY

  • Detail
  • TCI America

  • (B3623)  Bis(phenylacetyl) Disulfide  >98.0%(HPLC)

  • 15088-78-5

  • 25g

  • 1,890.00CNY

  • Detail
  • Alfa Aesar

  • (L19792)  Bis(phenylacetyl) disulfide, 98%   

  • 15088-78-5

  • 5g

  • 334.0CNY

  • Detail
  • Alfa Aesar

  • (L19792)  Bis(phenylacetyl) disulfide, 98%   

  • 15088-78-5

  • 25g

  • 1076.0CNY

  • Detail
  • Aldrich

  • (554324)  Phenylacetyldisulfide  96%

  • 15088-78-5

  • 554324-25G

  • 974.61CNY

  • Detail

15088-78-5SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 11, 2017

Revision Date: Aug 11, 2017

1.Identification

1.1 GHS Product identifier

Product name Phenylacetyl disulfide

1.2 Other means of identification

Product number -
Other names Bis-phenylacetyl-disulfan

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:15088-78-5 SDS

15088-78-5Relevant articles and documents

Synthesis of antisense oligonucleotides: Replacement of 3H-1,2-benzodithiol-3-one 1,1-dioxide (Beaucage reagent) with phenylacetyl disulfide (PADS) as efficient sulfurization reagent: From bench to bulk manufacture of active pharmaceutical ingredient

Cheruvallath, Zacharia S.,Carty, Recaldo L.,Moore, Max N.,Capaldi, Daniel C.,Krotz, Achim H.,Wheeler, Patrick D.,Turney, Brett J.,Craig, Stephen R.,Gaus, Hans J.,Scozzari, Anthony N.,Cole, Douglas L.,Ravikumar, Vasulinga T.

, p. 199 - 204 (2000)

It is demonstrated that phosphorothioate oligodeoxyribonucleotides can be synthesized on scales from 1 μmol to 150 mmol using phenylacetyl disulfide (PADS) as an efficient and economical replacement for Beaucage reagent. A 0.2 M solution of PADS in a mixt

Diacyl Disulfide: A Reagent for Chemoselective Acylation of Phenols Enabled by 4-(N,N-Dimethylamino)pyridine Catalysis

Liu, Hong-Xin,Dang, Ya-Qian,Yuan, Yun-Fei,Xu, Zhi-Fang,Qiu, Sheng-Xiang,Tan, Hai-Bo

supporting information, p. 5584 - 5587 (2016/11/17)

A general and excellent acylation reagent, diacyl disulfide, was uncovered for efficient ester formation enabled by DMAP (4-(N,N-dimethylamino)pyridine) catalysis. This protocol offered a promising synthetic platform on site-selective acylation of phenolic and primary aliphatic hydroxyl groups, which greatly expanded the realm of protecting group chemistry. The importance of the reagent was also reflected by its excellent moisture tolerance, high efficiency, and potential in synthetic chemistry and biologically meaningful natural product modification.

Synthesis of diacyl disulfides using a polymer supported reagent

Tamami,Kiasat

, p. 1275 - 1280 (2007/10/03)

Various diacyl disulfides are prepared easily in high yields from the corresponding acid chlorides under mild and non-aqueous conditions using a polymer supported reagent obtained from elemental sulfur and Amberlyst (OH)- . The polymeric reagent is regenerable.

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