150884-51-8

Basic information

• Product Name: (4-CYANO-BENZYLIDENE)-CARBAMIC ACID TERT-BUTYL ESTER
• Synonyms: 4-CYANO-N-BOC-BENZALDIMINE;(4-CYANO-BENZYLIDENE)-CARBAMIC ACID TERT-BUTYL ESTER;Carbamic acid, N-[(4-cyanophenyl)methylene]-, 1,1-dimethylethyl ester;tert-butyl 4-cyanobenzylidenecarbamate
• CAS NO: 150884-51-8
• Molecular Formula: C₁₃H₁₄N₂O₂
• Molecular Weight: 230.26
• Mol File: 150884-51-8.mol
• Article Data: 8

Chemical Properties

• Melting Point: 85-87 °C
• Boiling Point: 349.7°Cat760mmHg
• Flash Point: 165.3°C
• Appearance: /
• Density: 1.03g/cm³
• Vapor Pressure: 4.63E-05mmHg at 25°C
• Refractive Index: 1.517
• PKA: -1.40±0.50(Predicted)
• CAS DataBase Reference: (4-CYANO-BENZYLIDENE)-CARBAMIC ACID TERT-BUTYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: (4-CYANO-BENZYLIDENE)-CARBAMIC ACID TERT-BUTYL ESTER(150884-51-8)
• EPA Substance Registry System: (4-CYANO-BENZYLIDENE)-CARBAMIC ACID TERT-BUTYL ESTER(150884-51-8)

Safety Data

• Hazardous Substances Data: 150884-51-8(Hazardous Substances Data)

Usage

General Description

(4-Cyano-benzylidene)-carbamic acid tert-butyl ester is a chemical compound that is commonly used in the field of organic synthesis. It is a cyanobenzylidene derivative that has a tert-butyl ester group attached to the carbamic acid functional group. (4-CYANO-BENZYLIDENE)-CARBAMIC ACID TERT-BUTYL ESTER is used as an intermediate in the synthesis of various organic compounds and pharmaceuticals. It has the potential to be a useful building block in the production of new drugs and other biologically active molecules. The chemical properties of this compound make it a valuable tool for researchers and chemists working in medicinal chemistry and drug discovery.

InChI:InChI=1/C13H14N2O2/c1-13(2,3)17-12(16)15-9-11-6-4-10(8-14)5-7-11/h4-7,9H,1-3H3/b15-9+

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 105-07-7 4-cyanobenzaldehyde 
• 4248-19-5 tert-butyl carbazate 
• 1070-19-5 N-(tert-butyloxycarbonyl) azide 
• 68014-21-1 triphenyl(t-butoxycarbonylimino)phosphorane 

Downstream Products

• 150884-56-3 N-tert-butyloxycarbonyl-3-(4-cyanophenyl)oxaziridine 
• 158807-35-3 trans-N-Boc-3-(4-cyanophenyl)oxaziridine 
• 158807-35-3 cis-N-Boc-3-(4-cyanophenyl)oxaziridine 
• 68014-21-1 triphenyl(t-butoxycarbonylimino)phosphorane 
• 130518-03-5 tert-butyl 2-((S)-2-methoxy-1-methyl-2-oxoethyl)hydrazinecarboxylate 
• 111652-20-1 N-(tert-butoxycarbonyl)glycine tert-butyl ester 
• 138371-45-6 2-N-(tert-butoxycarbonyl)amino-1-phenyl-1-propanone 
• 145889-50-5 3-(2-tert-butoxycarbonylamino-1-oxo-3-phenylpropyl)-1,3-oxazolidin-2-one 
• 16257-32-2 L-N-(tert-butoxycarbonylamino)phenylalanine 
• 150884-50-7 benzaldehyde N-boc imine 
• 150884-54-1 N-(tert-butoxycarbonylamino)morpholine 
• 77821-22-8 (S)-1-tert-butoxycarbonylaminopyrrolidine-2-carboxylic acid 
• 163226-27-5 tert-butyl 3,4-dichlorobenzylidenecarbamate 
• 163226-26-4 tert-butyl 2,4-dichlorobenzylidenecarbamate 

Relevant articles and documents

Synthesis of highly substituted 2-spiropiperidines

2-Spiropiperidines are a highly desirable, yet under represented structure in drug discovery. 2-Spiropiperidines were synthesised in either a two-pot or one-pot reaction. In the two-pot reaction, the addition of a Weiler dianion to N-Boc imines, followed by deprotection and in situ condensation with a cyclic ketone generated functionalised 2-spiropiperidines in good to excellent yields. In the one-pot reaction, the addition of Chan's diene to N-Boc imines under Maitland-Japp conditions, followed by the addition of sodium bicarbonate and a cyclic ketone formed functionalised 2-spiropiperidines in moderate to good yields.

PYRAZOLE AMIDE DERIVATIVE

The present invention relates to a novel compound having a function of inhibiting RORγ activity. The present invention also relates to pharmaceutical composition comprising the compound, a use of the compound in treating or preventing autoimmune diseases, inflammatory diseases, metabolic diseases, or cancer diseases.

Rhodium(III)-catalyzed arylation of Boc-imines via C-H bond functionalization

The first rhodium-catalyzed arylation of imines proceeding via C-H bond functionalization is reported. Use of a non-coordinating halide abstractor is important to obtain reactivity. Aryl-branched N-Boc-amines are formed, and a wide range of functionality is compatible with the reaction.