150886-17-2Relevant academic research and scientific papers
Synthesis of thieno[2,3-b]pyridines with an oxalamidic acid or an oxalamidic alkylester residue and of 4-alkoxy-pyrido[3',2':4,5]thieno]3,2-d]pyrimidine-2-carboxylic acid derivatives
Wagner,Leistner,Vieweg,Krasselt,Prantz
, p. 342 - 346 (2007/10/02)
N-(2-Alkoxycarbonyl-thieno[2,3-b]pyrid-3-yl)oxalamide acid alkylester B were synthesized by the reaction of 3-amino-2-carboxylic esters A with oxalic acid diethylester in presence of sodium alkoxides. The 3-amino-2-cyano-thieno[2,3-b]pyridines C yielded under the same conditions via the N- (2-cyano-thieno[2,3-b]pyrid-3-yl)oxalamidic acid alkylesters D/1-D/4 the 4-alkoxy-pyrido[3',2': 4,5]thieno[3,2-d]pyrimidine-2-carboxylic acid alkylesters E/1-E/8. The compounds D/1, D/2 and E/1-E/5 were hydrolyzed to give the corresponding carboxylic acids. The 3-amino-furo[2,3-b]pyridine-2-carboxylic acid ethylester H reacted with oxalic ethylester chloride to give the oxalamide ethylester I. The synthesized substances showed an antianaphylactic activity.
