150930-95-3Relevant academic research and scientific papers
Studies on the photochemistry of taxol
Chen,Farina,Huang,Gao,Golik,Doyle
, p. 8633 - 8650 (2007/10/02)
Irradiation of taxol at 280 nm in a Rayonet reactor yielded a novel pentacyclic derivative containing a new bond between C-3 and C-11. The proposed mechanism involves a triplet intermediate and the first event of the oxa-di-π-methane rearrangement. Taxane
A facile synthesis of 7,10-dideoxy taxol and 7-epi-10-deoxy taxol
Chen,Wei,Vyas,Doyle,Farina
, p. 6845 - 6848 (2007/10/02)
7,10-Dideoxy taxol 2 was prepared from baccatin III in 4 steps via the Barton deoxygenation reaction. Similarly, 7-epi-10-deoxy taxol 3 was prepared in one step from 7-epi taxol in high yield. The key reaction was the tributyltin hydride-mediated directed reduction of the C10 acetate.
Synthesis of 7-Deoxy- and 7,10-Dideoxytaxol via Radical Intermediates
Chen, Shu-Hui,Huang, Stella,Kant, Joydeep,Fairchild, Craig,Wei, Jianmei,Farina, Vittorio
, p. 5028 - 5029 (2007/10/02)
7-Deoxytaxol and 7,10-dideoxytaxol were prepared from baccatin III, employing the Barton deoxygenation procedure and the Holton acylation method at C-13.
