150930-83-9

Upstream product

• 150930-96-4 C₃₇H₅₂O₁₀Si 
• 214192-74-2 7-deshydroxy-13-deshydro baccatine III 
• 146257-44-5 9-O-Acetyl-5-O-cinnamoyltaxicine I 
• 214192-72-0 C₂₃H₂₈O₉ 
• 214192-67-3 C₂₃H₃₀O₁₀ 
• 214192-73-1 C₂₅H₃₀O₁₀ 
• 214192-68-4 C₂₉H₄₄O₁₀Si 
• 214192-65-1 C₃₂H₃₄O₉ 
• 214192-64-0 10-O-Acetyl-5-O-cinnamoyltaxicine 1,2-carbonate 
• 214192-70-8 C₂₄H₃₂O₁₂S 
• 214192-69-5 C₃₀H₄₆O₁₂SSi 
• 262288-61-9 9-O-Acetyl-5-O-cinnamoyltaxicine 1,2-carbonate 
• 214192-66-2 C₃₂H₃₈O₁₃ 
• 1125-88-8 benzaldehyde dimethyl acetal 

Downstream Products

• 333327-25-6 C₃₂H₄₀O₈ 
• 173422-31-6 C₃₁H₃₈O₉S₂ 
• 149705-85-1 7-deoxypaclitaxel 
• 173422-30-5 (1S,2S,3R,4S,5R,7S,8R,10R,13S)-4-acetoxy-2-benzoyloxy-5,20-epoxy-9-oxo-1,10,13-trihydroxytax-11-ene 

Relevant academic research and scientific papers

Taxanes having an alkyl substituted side-chain and pharmaceutical compositions containing them

Taxane derivatives having an alkyl substituted C13 side chain.

C13 amido substituted taxane derivatives and pharmaceutical compositions containing them

Taxane derivatives having an amino substituted C13 side chain.

An efficient semisynthesis of 7-deoxypaclitaxel from taxine

A semisynthesis of 7-deoxypaclitaxel 4 is described, starting from taxine 6 - the most abundant naturally occurring taxane diterpene fraction. A key step in this transformation is a tandem reaction: stereoselective osmylation of cinnamic ester 14/intramolecularly assisted methanolysis of 16, which gives the key intermediate 5, along with the optically pure ester 17 - a precursor for the synthesis of the paclitaxel side-chain. In this way, the cinnamoyltaxicine 9 is converted into 7-deoxybaccatin III 25 in 11 steps, and in 15% overall yield.

An efficient semisynthesis of 7-deoxypaclitaxel from taxine

Highly cytotoxic 7-deoxypaclitaxel analogues are obtained by a semisynthesis starting from taxine - the most abundant naturally occurring taxane diterpene fraction.

Taxoids: 7-Deoxy-10-acetyldocetaxel and new analogs prepared from the yew tree alkaloids

Three new 7-deoxydocetaxel derivatives have been prepared from natural taxine B and isotaxine B: the first one, 2-debenzoyl-9-dihydro-1,2-O-benzylidine-9,10-O-isopropylidene-7-deoxydocetaxel has a slight cytotoxicity and a weak microtubule disassembly inhibitory activity; the other two derivatives, 9-dihydro-9,10-O-isopropylidene-7-deoxydocetaxel and 7-deoxy-10-acetyldocetaxel are cytotoxic and reveal a good microtubule disassembly inhibitory activity.

Synthesis of 7-Deoxy- and 7,10-Dideoxytaxol via Radical Intermediates

7-Deoxytaxol and 7,10-dideoxytaxol were prepared from baccatin III, employing the Barton deoxygenation procedure and the Holton acylation method at C-13.