150943-34-3Relevant academic research and scientific papers
An enantiospecific synthesis of the human cytomegalovirus antiviral agent [(R)-3-((2-amino-1,6-dihydro-6-oxo-9H-purin-9-yl)methoxy)-4- hydroxybutyl]phosphonic acid
Chamberlain,Biron,Dornsife,Averett,Beauchamp,Koszalka
, p. 1371 - 1377 (2007/10/02)
The racemic isosteric phosphonate of ganciclovir monophosphate (BW2482U89, SR3745, [3-((2-amino-1,6-dihydro-6-oxo-9H-purin-9-yl)methoxy)-4- hydroxybutyl]phosphonic acid, 1) has potent and selective in vitro activity against human cytomegalovirus. An enant
Total Synthesis of Amphoteronolide B and Amphotericin B. 1. Strategy and Stereocontrolled Construction of Key Building Blocks
Nicolaou, K. C.,Daines, R. A.,Uenishi, J.,Li, W. S.,Papahatjis, D. P.,Chakraborty, T. K.
, p. 4672 - 4685 (2007/10/02)
The retrosynthetic analysis and strategy for the total synthesis of amphotericin B (1) and amphoteronolide B (2) is discussed.Focusing on subtle and repeated structural units, a retrosynthetic scheme was constructed that led to the recognition of readily
