150969-58-7

Upstream product

• 24398-88-7 ethyl 3-bromobenzoate 
• 1066-54-2 trimethylsilylacetylene 
• 58313-23-8 3-iodobenzoic acid methyl ester 

Downstream Products

• 178742-95-5 ethyl 3-(ethynyl)benzoate 
• 835595-10-3 3-(1-benzyl-5,6-dichloro-1H-indol-2-yl)benzoic acid 
• 835595-13-6 3-(5,6-dichloro-1H-indol-2-yl)benzoic acid ethyl ester 
• 835595-02-3 3-(5,6-dichloro-1-methylindol-2-yl)benzoic acid 
• 835595-05-6 3-(5-chloro-1-benzofuran-2-yl)benzoic acid 
• 10601-99-7 3-ethynylbenzoic acid 
• 1262847-43-7 3-{3-[4-(4-methylpiperazin-1-yl)phenyl]isoxazol-5-yl}benzoic acid 
• 1262845-65-7 N-isopropyl-3-{3-[4-(4-methylpiperazin-1-yl)phenyl]isoxazol-5-yl}benzamide 
• 1262845-64-6 3-{3-[4-(4-methylpiperazin-1-yl)phenyl]isoxazol-5-yl}benzoic acid ethyl ester 
• 29203-58-5 4-bromo-N-hydroxybenzenecarboximidoyl chloride 
• 25062-46-8 4-bromobenzaldehyde oxime 

Relevant academic research and scientific papers

Cobalt-Catalyzed Hydroalkynylation of Vinylaziridines

Transition metal-catalyzed hydroalkynylation reactions are efficient transformations allowing the straightforward formation of functionalized alkynes. Therein, we disclose the cobalt-catalyzed hydroalkynylation of vinylaziridines giving rise to both linea

Ynonylation of Acyl Radicals by Electroinduced Homolysis of 4-Acyl-1,4-dihydropyridines

Herein we report the conversion of 4-Acyl-1,4-dihydropyridines (DHPs) into ynones under electrochemical conditions. The reaction proceeds via the homolysis of acyl-DHP under electron activation. The resulting acyl radicals react with hypervalent iodine(III) reagents to form the target ynones or ynamides in acceptable yields. This mild reaction condition allows wider functionality tolerance that includes halides, carboxylates, or alkenes. The synthetic utility of this methodology is further demonstrated by the late-stage modification of complex molecules.

Design, Synthesis, and Evaluation of Triazole Derivatives That Induce Nrf2 Dependent Gene Products and Inhibit the Keap1-Nrf2 Protein-Protein Interaction

The transcription factor Nrf2 regulates the expression of a large network of cytoprotective and metabolic enzymes and proteins. Compounds that directly and reversibly inhibit the interaction between Nrf2 and its main negative regulator Keap1 are potential pharmacological agents for a range of disease types including neurodegenerative conditions and cancer. We describe the development of a series of 1,4-diphenyl-1,2,3-triazole compounds that inhibit the Nrf2-Keap1 protein-protein interaction (PPI) in vitro and in live cells and up-regulate the expression of Nrf2-dependent gene products.

ARYLPYRAZOLES AND ARYLISOXAZOLES AND THEIR USE AS PKD MODULATORS

The present invention provides novel organic compounds of formula (I) or (Ia): which may be inhibitors of a selective subset of kinases belonging to the AGC or calmodulin kinase family, such as for example PKD-1/2/3, inhibitors of histone deacetylase (HDA

NOVEL COMPOUNDS

Compounds of the formula (I) are disclosed which are large conductance calcium activated potassium channel openers (BK channels openers) and are useful in the treatment of urinary tract disorders: (I), or a pharmaceutically acceptable salt thereof.

DICARBA-closo-DODECABORANE DERIVATIVES

A medicament comprising as an active ingredient a compound or a physiologically acceptable salt thereof represented by general formula (I): wherein R1 represents a dicarba-closo-dodecaboran-yl which may be substituted with a lower alkyl group,

Dicarba-closo-dodecaboranes as a pharmacophore. Retinoidal antagonists and potential agonists

Synthesis and biological evaluation of the first dicarba-closo- dodecaborane (carborane) derivatives of retinoids are described. Their retinoidal activity were examined in terms of the differentiation-inducing ability toward human promyelocytic leukemia HL-60 cells. High retinoidal activity (agonist or antagonist for retinoic acid receptor (RAR)) requires a carboxylic acid moiety and an appropriate hydrophobic group located at a suitable position on the molecule. The 4-carboranyl-substituted compounds (7, 11) showed antagonistic activity but no agonistic activity even in the presence of the potent synergist HX630. On the other hand, the 3-carboranyl- substituted compounds (8, 12) showed potential agonistic activity, but no antagonistic activity. The results indicates that carboranes are applicable as the hydrophobic moiety of biologically active molecules.