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150985-52-7 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 150985-52-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,5,0,9,8 and 5 respectively; the second part has 2 digits, 5 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 150985-52:
147 % 10 = 7
So 150985-52-7 is a valid CAS Registry Number.



According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017


1.1 GHS Product identifier

Product name 1-ethyl-2-(6-methoxy-1-benzofuran-2-yl)imidazole,hydrochloride

1.2 Other means of identification

Product number -
Other names -

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:150985-52-7 SDS

150985-52-7Downstream Products

150985-52-7Relevant articles and documents

Benzofuranyl-2-imidazoles as imidazoline I2 receptor ligands for Alzheimer's disease

Brocos-Mosquera, Iria,Callado, Luis F.,Daelemans, Dirk,De Jonghe, Steven,Djikic, Teodora,Escolano, Carmen,Loza, M. Isabel,Molins, Elies,Nikolic, Katarina,Radan, Milica,Vasilopoulou, Foteini,Bagán, Andrea,Brea, José,García-Fuster, M. Julia,García-Sevilla, Jesús A.,Gri?án-Ferré, Christian,Hernández-Hernández, Elena,Martínez, Antón L.,Pérez, Belén,Pallàs, Mercè,Rodriguez-Arévalo, Sergio

, (2021/07/28)

Recent findings unveil the pharmacological modulation of imidazoline I2 receptors (I2-IR) as a novel strategy to face unmet medical neurodegenerative diseases. In this work, we report the chemical characterization, three-dimensional quantitative structure-activity relationship (3D-QSAR) and ADMET in silico of a family of benzofuranyl-2-imidazoles that exhibit affinity against human brain I2-IR and most of them have been predicted to be brain permeable. Acute treatment in mice with 2-(2-benzofuranyl)-2-imidazole, known as LSL60101 (garsevil), showed non-warning properties in the ADMET studies and an optimal pharmacokinetic profile. Moreover, LSL60101 induced hypothermia in mice while decreased pro-apoptotic FADD protein in the hippocampus. In vivo studies in the familial Alzheimer's disease 5xFAD murine model with the representative compound, revealed significant decreases in the protein expression levels of antioxidant enzymes superoxide dismutase and glutathione peroxidase in hippocampus. Overall, LSL60101 plays a neuroprotective role by reducing apoptosis and modulating oxidative stress.

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