150989-01-8

Usage

Uses

Used in Pharmaceutical Industry:
(E)-Tetradec-9-enoyl chloride is used as a reagent for the synthesis of various bioactive compounds. Its unique chemical structure allows for the creation of a wide range of organic compounds, including fatty acids, esters, and amides, which can be utilized in the development of pharmaceutical products.
Used in Agrochemical Industry:
In the agrochemical sector, (E)-Tetradec-9-enoyl chloride is employed as a key intermediate in the production of compounds with biological activity. These compounds can be used in the development of pesticides, herbicides, and other agrochemical products to enhance crop protection and yield.

Upstream product

• 544-64-9 myristoleic acid 
• 50286-30-1 tetradec-9-enoic acid 

Relevant academic research and scientific papers

IMPROVED COMPOSITIONS AND METHODS FOR THE DELIVERY OF NUCLEIC ACIDS

The present invention provides compositions and methods for the delivery of therapeutic agents to cells. In particular, these include novel lipids and nucleic acid-lipid particles that provide efficient encapsulation of nucleic acids and efficient delivery of the encapsulated nucleic acid to cells in vivo. The compositions of the present invention are highly potent, thereby allowing effective knock-down of specific target protein at relatively low doses. In addition, the compositions and methods of the present invention are less toxic and provide a greater therapeutic index compared to compositions and methods previously known in the art.

Vanilloids. 1. Analogs of Capsaicin with Antinociceptive and Antiinflammatory Activity

As part of a program to establish structure-activity relationships for vanilloids, analogs of the pungent principle capsaicin, the alkyl chain portion the parent structure (and related compounds derived from homovanillic acid) was varied.In antinociceptive and antiinflammatory assays (rat and mouse hot plate and croton oil-inflamed mouse ear), compounds with widely varying alkyl chain structures were active.Short-chain compounds were active by systemic administration in the assays mentioned above but they retained the high pungency and acute toxicity characteristic of capsaicin.In contrast, the long chain cis-unsaturates, NE-19550 (vanillyloleamide) and NE-28345 (oleylhomovanillamide), were orally active, less pungent, and less acutely toxic than capsaicin.The potential of these compounds as antiinflammatory/analgesic agents is discussed in light of recent data on the mechanism of action of vanilloids on sensory nerve fibers.