150989-57-4Relevant academic research and scientific papers
Concise syntheses of stereoisomeric hexahydroazepine derivatives related to the protein kinase inhibitor balanol
Roy, Sankar P.,Chattopadhyay, Shital K.
, p. 5498 - 5501 (2008/12/22)
A stereodivergent route to four stereoisomeric azepane derivatives related to the important protein kinase inhibitor balanol is developed which utilises (-)- or (+)-serine as starting material, and a ring-closing metathesis as the key ring forming step.
An asymmetric aminohydroxylation approach to the azepine core of (-)-balanol
Masse, Craig E.,Morgan, Adam J.,Panek, James S.
, p. 2571 - 2573 (2007/10/03)
(equation presented) An efficient formal synthesis of the potent protein kinase C inhibitor (-)-balanol that relies on a modified asymmetric aminohydroxylation of the α,β-unsaturated aryl ester (1) is reported. The aryl ester functionality and the dihydroquinyl alkaloid ligand system (DHQ)2-AQN are used to control the regio- and enantioselectivity of the process.
Total Synthesis of (-)-Balanol
Lampe, John W.,Hughes, Philip F.,Biggers, Christopher K.,Smith, Shelley H.,Hu, Hong
, p. 5147 - 5148 (2007/10/02)
(-)-Balanol, a fungal metabolite with potent protein kinase C inhibitory properties, has been prepared in a total synthesis which makes use of an anionic homo-Fries rearrangement approach to the benzophenone subunit and in which the azepane subunit is obt
