151062-79-2Relevant academic research and scientific papers
Lewis Acid-Promoted 1,4-Addition to Chiral Imide Derivatives in the Synthesis of β-Amino Acids
Amoroso, Rosa,Cardillo, Giuliana,Sabatino, Piera,Tomasini, Claudia,Trere, Alessandra
, p. 5615 - 5619 (2007/10/02)
The 1,4-addition of O-benzylhydroxylamine to imides 3 in the presence of various Lewis acids is described.The reaction is performed in CH2Cl2 at -78 deg C and affords derivatives 4 and 5 in good chemical yields and in different diastereomeric ratios, depending on the Lewis acid employed.TiCl4 and Me2AlCl give opposite diastereoselectivities.Furthemore, enantiomerically pure β-amino acid 9 is obtained in good yield from compound 4a.
