151073-40-4Relevant academic research and scientific papers
Ligand-free palladium catalysed Heck reaction of methyl 2-acetamido acrylate and aryl bromides as key step in the synthesis of enantiopure substituted phenylalanines
Willans, Charlotte E.,Mulders, Jan M.C.A.,de Vries, Johannes G.,de Vries, André H.M.
, p. 494 - 497 (2003)
A range of substituted aryl bromides were coupled with methyl 2-acetamido acrylate using ligand-free palladium catalysis. Subsequently asymmetric hydrogenation with Rh/MonoPhos yielded substituted phenylalanines in high enantioselectivities (e.e. 92-99%).
An Atropos Chiral Biphenyl Bisphosphine Ligand Bearing Only 2,2′-Substituents and Its Application in Rh-Catalyzed Asymmetric Hydrogenation
Jia, Jia,Ling, Zheng,Zhang, Zhenfeng,Tamura, Ken,Gridnev, Ilya D.,Imamoto, Tsuneo,Zhang, Wanbin
supporting information, p. 738 - 743 (2017/12/26)
An atropos chiral biphenyl bisphosphine ligand bearing only 2,2′-substituents was rationally designed and easily synthesized utilizing a bulky chiral t-butylmethylphosphino block. Computational results showed a large difference in the free energies betwee
Chemo-enzymatic synthesis of chiral fluorine-containing building blocks
Blaauw, Richard H.,IJzendoorn, Denis R.,Cremers, Jozef G. O.,Rutjes, Floris P. J. T.,Broxterman, Quirinus B.,Schoemaker, Hans E.
, p. 104 - 107 (2007/10/03)
Two complementary strategies for the synthesis of optically active fluorine-containing building blocks have been probed. The first strategy involves either the enzymatic resolution of fluorinated α,α- disubstituted-α-amino acid amides, or the asymmetric h
