1510798-88-5

Basic information

• Product Name: tert-butyl 2-benzyl-2-cyanopiperidine-1-carboxylate
• Synonyms: tert-butyl 2-benzyl-2-cyanopiperidine-1-carboxylate
• CAS NO: 1510798-88-5
• Molecular Weight: 300.401
• Mol File: 1510798-88-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: tert-butyl 2-benzyl-2-cyanopiperidine-1-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-butyl 2-benzyl-2-cyanopiperidine-1-carboxylate(1510798-88-5)
• EPA Substance Registry System: tert-butyl 2-benzyl-2-cyanopiperidine-1-carboxylate(1510798-88-5)

Safety Data

• Hazardous Substances Data: 1510798-88-5(Hazardous Substances Data)

Upstream product

• 153749-89-4 2-cyanopiperidine-1-carboxylic acid tert-butyl ester 
• 1510799-34-4 tert-butyl 2-cyano-2-(pyridin-2-ylthio)piperidine-1-carboxylate 
• 100-39-0 benzyl bromide 

Relevant articles and documents

Arylthio-metal exchange of α-arylthioalkanenitriles

The addition of BuLi, Bu3MgLi, Et2ZnBuLi, or Me 2CuLi to α-arylthioalkanenitriles triggers an arylthio-metal exchange. NMR spectroscopic analyses implicate organometallic attack on sulfur forming a three-coordinate sulfidate as the key intermediate. Electrophilic trapping affords tertiary and quaternary nitriles in high yield. The method addresses the challenge of improving the functional group tolerance and preventing polyalkylations.