15116-19-5

Upstream product

• 186581-53-3 diazomethane 
• 533-24-4 4-pentyl resorcinol 
• 2880-58-2 2-methoxy-1,4-benzoquinone 
• 142-62-1 hexanoic acid 
• 67-56-1 methanol 
• 161691-33-4 2-pentylcyclohexa-2,5-diene-1,4-dione 
• 109-52-4 valeric acid 
• 85696-82-8 2-pentanyl-5-methoxyphenol 
• 372486-18-5 1-(2-hydroxy-4-methoxyphenyl)pentan-1-one 
• 15116-13-9 1-(2,4-dihydroxyphenyl) pentan-1-one 
• 108-46-3 recorcinol 
• 1883-38-1 tripentylborane 

Relevant academic research and scientific papers

A Catalytic Oxidative Quinone Heterofunctionalization Method: Synthesis of Strongylophorine-26

The preparation of heteroatom-substituted p-quinones is ideally performed by direct addition of a nucleophile followed by in situ reoxidation. Albeit an appealing strategy, the reactivity of the p-quinone moiety is not easily tamed and no broadly applicable method for heteroatom functionalization exists. Shown herein is that Co(OAc)2 and Mn(OAc)3?2 H2O act as powerful catalysts for oxidative p-quinone functionalization with a collection of O, N, and S nucleophiles, using oxygen as the terminal oxidant. Preliminary mechanistic observations and the first synthesis of the cytotoxic natural product strongylophorine-26 is presented.

Primulin derivative as well as synthesis method and application of primulin derivative

The invention discloses a primulin derivative with antibacterial activity shown as the structural general formula (I), wherein R is selected from C2-C20 alkyls. The primulin derivative is prepared from raw materials including m-dihydroxybenzene and a fatty acid derivative by the steps: carrying out Friedel-Crafts acylation and methylation to synthesize a paeonol derivative, and carrying out oxidization after carrying out carbonyl reduction. The primulin derivative has good antibacterial activity and can be used as a potential antibacterial agent.

Regioselective alkylation of substituted quinones by trialkylboranes

2-Methoxy-1,4-benzoquinone can be alkylated selectively with trialkrylboranes in position 5, giving high yields of 5-alkyl-2-methoxy-1,4- benzoquinones after oxidative work up. In the case of 2-hydroxy- 1,4naphthoquinone, the same procedure leads to 3-alkylated products. A radical chain mechanism is proposed to explain the observed selectivity.