15121-85-4Relevant academic research and scientific papers
Probing cytochrome P450 (CYP) bioactivation with chloromethylindoline bioprecursors derived from the duocarmycin family of compounds
Ortuzar, Natalia,Karu, Kersti,Presa, Daniela,Morais, Goreti R.,Sheldrake, Helen M.,Shnyder, Steve D.,Barnieh, Francis M.,Loadman, Paul M.,Patterson, Laurence H.,Pors, Klaus,Searcey, Mark
, (2021/05/04)
The duocarmycins belong to a class of agent which has great potential for use in cancer therapy. Their exquisite potency means they are too toxic for systemic use, and targeted approaches are required to unlock their clinical potential. In this study, we
Post-Assembly Photomasking of Potassium Acyltrifluoroborates (KATs) for Two-Photon 3D Patterning of PEG-Hydrogels
Song, Haewon,Wu, Dino,Mazunin, Dimitry,Liu, Sizhou M.,Sato, Yoshikatsu,Broguiere, Nicolas,Zenobi-Wong, Marcy,Bode, Jeffrey W.
, (2020/10/22)
Chemical ligation reactions of functional groups that can be masked with two-photon labile protecting groups provide a powerful technology for the three-dimensional patterning of molecules – including proteins – onto hydrogel scaffolds. In order to utiliz
A chemoselective photolabile protecting group for aldehydes
Peng, Tao,Wang, Gang,Wang, Lin,Wen, Xiaoxue,Xu, Jing,Xu, Kaijun,Yang, Hongpeng,Zhang, Shouguo
supporting information, (2020/02/29)
A new and high-efficiency photolabile protecting group (PLPG) for aldehydes is described. The PLPG was introduced to aldehydes by using a Lewis acid. Results showed that the PLPG can be released rapidly and smoothly under ultraviolet (UV) irradiation with high efficiency and low cost. This PLPG can easily synthesized and also be selectively protect aldehydes in the presence of ketones.
Convenient and scalable process for the preparation of indole via raney nickel-catalyzed hydrogenation and ring closure
Guo, Xianghai,Peng, Zhiliang,Jiang, Shende,Shen, Jiaxiang
scheme or table, p. 2044 - 2052 (2011/08/03)
An efficient and practical method for the synthesis of indole as a key starting material for many useful chemicals is described. Using 2-nitrotoluene as starting material, hydroxymethylation with formaldehyde under alkaline conditions gave 2-(2-nitrophenyl) ethanol on a large scale. Raney Ni catalyst was used for both reduction of the nitro group as well as for the indole formation. The overall yield was 78% from 2-nitrotoluene. Copyright
Electrogenerated Base (EG Base) Induced Hydroxymethylation of the Side Chain of Nitroalkylbenzenes with Paraformaldehyde
Torii, Sigeru,Murakami, Yasuo,Tanaka, Hideo,Okamoto, Koichi
, p. 3143 - 3147 (2007/10/02)
Hydroxymethylation of nitroalkylbenzenes with paraformaldehyde was accomplished by electrolysis in a (CH2O)n-DMF-Et4NOTs-(Pt electrode) system.The reaction was found to be catalytic (0.25 faraday/mol) and dependent on the electroreduction of formaldehyde and/or nitroalkylbenzene.A variety of nitroalkylbenzenes were transformed to their corresponding mono- and/or bishydroxymethylated derivatives in good yield.The product yield and selectivity were shown to depend on the order of reagent addition, solvent, supporting electrolyte, and structure of the starting nitroalkylbenzenes.A plausible mechanism of the generation of base catalysts (EG base) in electroreductive media is discussed.
