130469-60-2Relevant academic research and scientific papers
An alternative and convenient strategy for generation of substantial quantities of singly 5′-32p-end-labeled double-stranded DNA for binding studies: Development of a protocol for examination of functional features of (+)-CC-1065 and the duocarmycins that contribute to their sequence-selective DNA alkylation properties
Boger, Dale L.,Munk, Stephen A.,Zarrinmayeh, Hamideh,Ishizaki, Takayoshi,Haught, Joan,Bina
, p. 2661 - 2682 (1991)
Development of an alternative strategy for securing substantial quantities of singly 5′-32P-end-labeled double-stranded DNA suitable for binding studies is described based on M133 cloning techniques and offers advantages of production of replenishable quantities of singly 5′-32P-end-labeled double-stranded.
Probing cytochrome P450 (CYP) bioactivation with chloromethylindoline bioprecursors derived from the duocarmycin family of compounds
Ortuzar, Natalia,Karu, Kersti,Presa, Daniela,Morais, Goreti R.,Sheldrake, Helen M.,Shnyder, Steve D.,Barnieh, Francis M.,Loadman, Paul M.,Patterson, Laurence H.,Pors, Klaus,Searcey, Mark
, (2021/05/04)
The duocarmycins belong to a class of agent which has great potential for use in cancer therapy. Their exquisite potency means they are too toxic for systemic use, and targeted approaches are required to unlock their clinical potential. In this study, we
