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151229-84-4

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151229-84-4 Usage

General Description

2,6-dichloropyridine-3,5-dicarbonitrile is a chemical compound with the molecular formula C7H2Cl2N2. It is a highly functionalized pyridine derivative that contains two nitrile groups and two chlorine atoms. 2,6-dichloropyridine-3,5-dicarbonitrile is commonly used in organic synthesis as a building block for the preparation of various pharmaceuticals, agrochemicals, and other fine chemicals. It is known for its reactivity and ability to undergo various chemical reactions, making it a versatile intermediate in the production of a wide range of organic compounds. Additionally, it has also been used as a starting material for the development of new materials and catalysts in the field of chemical research.

Check Digit Verification of cas no

The CAS Registry Mumber 151229-84-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,5,1,2,2 and 9 respectively; the second part has 2 digits, 8 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 151229-84:
(8*1)+(7*5)+(6*1)+(5*2)+(4*2)+(3*9)+(2*8)+(1*4)=114
114 % 10 = 4
So 151229-84-4 is a valid CAS Registry Number.

151229-84-4SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name 2,6-dichloropyridine-3,5-dicarbonitrile

1.2 Other means of identification

Product number -
Other names 2,6-dichloro-3,5-dicyanopyridine

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:151229-84-4 SDS

151229-84-4Relevant articles and documents

Discovery of Novel Pyrido-pyridazinone Derivatives as FER Tyrosine Kinase Inhibitors with Antitumor Activity

Taniguchi, Toru,Inagaki, Hiroaki,Baba, Daichi,Yasumatsu, Isao,Toyota, Akiko,Kaneta, Yasuyuki,Kiga, Masaki,Iimura, Shin,Odagiri, Takashi,Shibata, Yoshihiro,Ueda, Kiyono,Seo, Maki,Shimizu, Hiroki,Imaoka, Tomoki,Nakayama, Kiyoshi

supporting information, p. 737 - 742 (2019/04/01)

To obtain a new anticancer drug, we focused on FER tyrosine kinase. Starting with high-throughput screening with our in-house chemical library, compound 1, which has a pyridine moiety, was found. Referring to their X-ray crystal structure with FES proto-oncogene tyrosine kinase, as a surrogate of FER followed by chemical modification including scaffold hopping of the pyridine template, we discovered pyrido-pyridazinone derivatives with potent FER kinase inhibitory activity. Here, we disclose the structure-activity relationship on the scaffold and representative compound 21 (DS21360717), which showed in vivo antitumor efficacy in a subcutaneous tumor model.

One pot synthesis of 2,6-dichloro-3,5-dicyanopyridine from aliphatic precursors

Duindam,Lishinsky,Sikkema

, p. 2605 - 2609 (2007/10/02)

Malononitrile is condensed with triethyl orthoformate in the presence of pyridine; the mixture is acidified with HCl gas and after addition of further pyridine, HCl diazotised to form 2,6-dichloro-3,5-dicyanopyridine in a convenient, high yield process.

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