15129-16-5Relevant academic research and scientific papers
I2-Mediated Oxidative C-N and N-S Bond Formation in Water: A Metal-Free Synthesis of 4,5-Disubstituted/N-Fused 3-Amino-1,2,4-triazoles and 3-Substituted 5-Amino-1,2,4-thiadiazoles
Jatangi, Nagesh,Tumula, Nagaraju,Palakodety, Radha Krishna,Nakka, Mangarao
, p. 5715 - 5723 (2018/05/15)
An environmentally benign and convenient strategy for the synthesis of 4,5-disubstituted/N-fused 3-amino-1,2,4-triazoles and 3-substituted 5-amino-1,2,4-thiadiazoles from isothiocyanates has been developed. This metal-free method involves I2-me
A facile one-pot synthetic method for 1,2,4-triazoles and 1,3-disubstituted thioureas
Singh, Okram Mukherjee,Singh, Sarangthem Joychandra
, p. 483 - 485 (2007/10/03)
The reaction of arylisothiocyanates with triethylamine and acylhydrazides in the presence of mercuric acetate has been studied. The reaction proceeds through the formation of thiourea, followed by a sequential addition-dehydration with acylhydrazides. The initial detection of thiourea, which mediates the formation of disubstituted 1,2,4-triazoles, is explained by a plausible mechanism.
