2039-00-1

Upstream product

• 15129-16-5 (4,5-diphenyl-4H-[1,2,4]triazol-3-yl)-phenyl-amine 
• 136169-36-3 N-carbamoyl-N''-phenyl-benzamidrazone 
• 17531-59-8 benzaldehyde N-phenylsemicarbazone 
• 20375-35-3 ethyl N-phenylcarbamoylmethane hydrazonate 
• 1152-32-5 1-benzoyl-4-phenylsemicarbazide 
• 98-07-7 Benzotrichlorid 
• 537-47-3 4-phenyl-semicarbazide 
• 5281-18-5 benzaldehyde, hydrazone 
• 55305-43-6 N-cyano-N-phenyl-p-toluenesulfonamide 
• 1422157-55-8 tert-butyl N-[[chloro(phenyl)methylene]amino]carbazate 
• 28867-76-7 benzaldehyde benzylidenehydrazone 
• 103-71-9 phenyl isocyanate 
• 71233-35-7 2,3,6,7-tetraphenyl-tetrahydro-[1,2,4]triazolo[1,2-a][1,2,4]triazole-1,5-dione 

Downstream Products

• 65091-72-7 4,5-diphenyl-2-pyrrolidin-1-ylmethyl-2,4-dihydro-[1,2,4]triazol-3-one 
• 65466-36-6 4,5-diphenyl-2-piperidin-1-ylmethyl-2,4-dihydro-[1,2,4]triazol-3-one 
• 65466-38-8 2-morpholin-4-ylmethyl-4,5-diphenyl-2,4-dihydro-[1,2,4]triazol-3-one 
• 97738-87-9 2-acetyl-4,5-diphenyl-2,4-dihydro-[1,2,4]triazol-3-one 
• 100087-97-6 2-benzoyl-4,5-diphenyl-2,4-dihydro-[1,2,4]triazol-3-one 
• 385367-89-5 1-(3-chloropropyl)-3,4-diphenyl-1,2,4-triazolin-5-one 
• 143547-42-6 8-(5-Oxo-3,4-diphenyl-4,5-dihydro-[1,2,4]triazol-1-yl)-octanoic acid 
• 143547-40-4 9-(5-Oxo-3,4-diphenyl-4,5-dihydro-[1,2,4]triazol-1-yl)-nonanoic acid 
• 864932-39-8 C₂₀H₁₄BrN₃O 
• 65091-81-8 4,5-diphenyl-2-(2-propynyl)-2,4-dihydro-3H-1,2,4-triazol-3-one 
• 1351071-29-8 4,5-diphenyl-2-[4-(2-methylpiperidino)-2-butynyl]-2,4-dihydro-3H-1,2,4-triazol-3-one 
• 1351071-31-2 4,5-diphenyl-2-[4-(3-methylpiperidino)-2-butynyl]-2,4-dihydro-3H-1,2,4-triazol-3-one 
• 1351071-33-4 C₂₂H₂₂N₄O 

Relevant academic research and scientific papers

Synthesis of 1,2,4-Triazol-3-imines via Selective Stepwise Cycloaddition of Nitrile Imines with Organo-cyanamides

A convenient method for the synthesis of 1,2,4-triazol-3-imines through a selective, formal, 1,3-dipolar cycloaddition of organo-cyanamide ions with nitrile imine dipoles is reported. Hydrolysis of the 1,2,4-triazol-3-imines yields the corresponding 1,2,4-triazol-5-ones. A stepwise mechanism, supported by DFT calculations, is invoked to explain the reaction selectivity.

Synthesis and antimicrobial evaluation of 4,5-diaryl-2-[4-(tamino)-2- butynyl]-2,4-dihydro-3H-1,2,4-triazol-3-ones

A series of 4,5-diaryl-2-[4-(t-Amino)-2-butynyl]-2,4-dihydro-3H-1,2,4- triazol-3-ones were synthesized and characterized by infrared spectrum (IR), 1H-NMR spectra and elemental analyses. Investigation of their antimicrobial activity was performed. Antimic

Synthesis of 4-phenyl-1,2,4-triazoline-5-one and 3,4-diphenyl-1,2,4-triazoline-5-one N1-derivatives

In the reaction of formic and benzoic acids hydrazide with isocyanates there were obtained semicarbazide derivatives which due to the cyclization in the basic medium gave 1,2,4-trazoline-5-one derivatives [Ia, b]. These compounds reacting with ethyl bromoacetate, ethyl chloroformate, allyl bromide, acetic anhydride, benzoyl chloride and in the aminomethylation and cyanoethylation reactions gave N1-derivatives of 1,2,4-triazoline-5-one [IIa, b-XIIa, b].

REACTION OF PHENYLTRICHLOROMETHANE WITH SEMICARBAZIDE AND THIOSEMICARBAZIDE DERIVATIVES

Phenyltrichloromethane 1 reacts with 4-phenylsemicarbazide and yields ethyl N-phenylcarbamoylmethane hydrazonate 10.Thermolysis of 10 yields 3,4-diphenyl-1H-1,2,4-triazolin-5-one 9a, identified by its alternate synthesis from the amidrazone 14 and dipheny