15131-80-3

Basic information

• Product Name: 2,2'-DIHYDROXYCHALCONE
• Synonyms: 1,3-bis(2-hydroxyphenyl)-2-propen-1-on;1,3-bis(2-hydroxyphenyl)-2-propen-1-one;2’-hydroxy-3-(o-hydroxyphenyl)-acrylophenon;2,2'-DIHYDROXYCHALCONE;1,3-DI(2-HYDROXYPHENYL)PROP-2-EN-1-ONE;2,2''-DIHYDROXYCHALCHONE;2-Propen-1-one, 1,3-bis(2-hydroxyphenyl)-;Acrylophenone, 2'-hydroxy-3-(o-hydroxyphenyl)-
• CAS NO: 15131-80-3
• Molecular Formula: C₁₅H₁₂O₃
• Molecular Weight: 240.25
• Product Categories: Chalcones
• Mol File: 15131-80-3.mol
• Article Data: 47

Chemical Properties

• Melting Point: 161-162°C
• Boiling Point: 447.1 °C at 760 mmHg
• Flash Point: 238.3 °C
• Appearance: /
• Density: 1.286 g/cm³
• PKA: 7.72±0.30(Predicted)
• CAS DataBase Reference: 2,2'-DIHYDROXYCHALCONE(CAS DataBase Reference)
• NIST Chemistry Reference: 2,2'-DIHYDROXYCHALCONE(15131-80-3)
• EPA Substance Registry System: 2,2'-DIHYDROXYCHALCONE(15131-80-3)

Safety Data

• RIDADR: UN 2811 6.1 / PGIII
• WGK Germany: 3
• Hazardous Substances Data: 15131-80-3(Hazardous Substances Data)

Usage

General Description

2,2'-dihydroxychalcone is a chemical compound belonging to the chalcone family, which is a type of flavonoid. It is a yellow crystalline solid with a molecular formula of C15H12O3. 2,2'-DIHYDROXYCHALCONE has been found to exhibit a variety of biological activities, including antioxidant, anti-inflammatory, and anticancer properties. It has been studied for its potential role in the treatment of various diseases and conditions, including cancer, diabetes, and neurodegenerative disorders. Additionally, 2,2'-dihydroxychalcone has been investigated for its potential use in food and cosmetic industries due to its antioxidant properties. Overall, this compound has shown promise in various applications, and further research is needed to fully understand its potential benefits and mechanisms of action.

Upstream product

• 118-93-4 o-hydroxyacetophenone 
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• 89-95-2 2-methyl-benzyl alcohol 
• 5533-04-0 2-(methoxymethoxy)benzaldehyde 
• 1006623-69-3 2′-hydroxyflavylium tetrafluoroborate 
• 31165-67-0 2'-benzyloxyacetophenone 
• 5896-17-3 2-(phenylmethoxy)benzaldehyde 

Downstream Products

• 17348-76-4 2'-hydroxyflavanone 
• 6068-76-4 3,2'-dihydroxyflavone 
• 99263-61-3 ((C₆H₄OH)HCCHCOC₆H₄O)3NbCl₂ 
• 35244-11-2 2'-hydroxyflavone 
• 74599-69-2 3-(2-Hydroxybenzyl)-chroman-4-on 

Relevant articles and documents

Hydroxychalcone dyes that serve as color indicators for pH and fluoride ions

A chalcone, which is composed of two aromatic rings bridged by an α,β-unsaturated carbonyl group, exhibits a variety of biological activities. With an objective to develop a novel chalcone-based functional dye, we have synthesized a chalcone diol CLN1, bearing two OH groups at the 2-positions on both phenyl rings, as well as reference compounds CLN2-6, and found that it serves as color indicators for pH and fluoride ions. CLN1showed a vivid color change from colorless to yellow (halochromism) in water at pH ≥ 10. Furthermore, it presented a selective color change from colorless to red upon the addition of TBAF in an organic solvent such as CH3CN. CLN1provided a strong red-shifted absorption band in the visible region under alkaline conditions in water and upon the addition of TBAF in CH3CN. The absorption spectral study together with TD-DFT calculations and X-ray crystallographic analysis revealed that the characteristic π-resonant structures of CLN1caused by the ionization or OH-F?interactions and the planar conformation due to its intramolecular hydrogen bonding may provide a strong charge transfer (CT) absorption in the visible region.

Effect of OH substitution in 3-benzylchroman-4-ones: crystallographic, CSD, DFT, FTIR, Hirshfeld surface, and energy framework analysis

3-Benzylchroman-4-ones (homoisoflavanones) are oxygen-containing heterocycles with a sixteen-carbon skeleton. They belong to the class of naturally occurring polyphenolic flavonoids with limited occurrence in nature and possess anti-inflammatory, antibact

Differences in antioxidant potential of chalcones in human serum: In vitro study

Introduction: An imbalance between oxidants and antioxidants in favour of oxidants, potentially leading to damage, is termed oxidative stress. Antioxidants (AO), either enzymatic or non-enzymatic, are the ones that can reduce diverse effects of pro-oxidan